QTL Gene Chr Start End SNPs Shared Percent SNPs Shared SNPs Uniquely Shared Percent SNPs Uniquely Shared SNP Sum Percent Shared Mammalian Phenotype Gene Ontology Mcvq5 Abhd6 14 8835416 8889069 388 57.4% 1 0.1% 676 57.5% "acylglycerol lipase activity; mitochondrion; catalytic activity; hydrolase activity; integral to membrane; membrane; acylglycerol lipase activity; long term synaptic depression; negative regulation of cell migration; regulation of endocannabinoid signaling pathway" Mcvq5 Rpp14 14 8912881 8924350 104 37.8% 2 0.7% 275 38.5% "hydrolase activity; nucleus; ribonuclease activity; ribonuclease P activity; tRNA processing; identical protein binding" Mcvq5 Pxk 14 8930757 8997624 548 42.2% 6 0.5% 1298 42.7% "cytoplasm; negative regulation of ATPase activity; negative regulation of ion transport; plasma membrane; actin binding; ATP binding; cell communication; membrane; phosphatidylinositol binding; protein kinase activity; protein phosphorylation; transferase activity, transferring phosphorus-containing groups; protein C-terminus binding; centrosome; cytoplasm; inflammatory response; nucleus; plasma membrane" Mcvq5 Pdhb 14 8998505 9005506 46 45.5% 0 0.0% 101 45.5% "mitochondrion; catalytic activity; glycolysis; metabolic process; oxidoreductase activity; acetyl-CoA biosynthetic process from pyruvate; mitochondrion; oxidation-reduction process; pyruvate dehydrogenase (acetyl-transferring) activity; pyruvate dehydrogenase complex; regulation of acetyl-CoA biosynthetic process from pyruvate" Mcvq5 Kctd6 14 9046662 9056081 83 63.8% 0 0.0% 130 63.8% "ion channel activity; membrane; potassium ion transport; voltage-gated potassium channel activity; voltage-gated potassium channel complex" Mcvq5 Acox2 14 9058025 9091867 176 35.3% 1 0.2% 499 35.5% "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; cellular lipid metabolic process; fatty acid beta-oxidation; fatty acid binding; flavin adenine dinucleotide binding; peroxisome" Mcvq5 Fam107a 14 9128788 9150537 178 51.9% 0 0.0% 343 51.9% "nucleus; regulation of cell growth; molecular_function" Mcvq5 Oit1 14 9181462 9211277 196 33.4% 0 0.0% 587 33.4% "extracellular region; negative regulation of insulin secretion; negative regulation of insulin secretion" Mcvq5 2610318M16Rik 14 9200823 9201059 3 42.9% 0 0.0% 7 42.9% "biological_process; cellular_component; molecular_function" Mcvq5 4930452B06Rik 14 9263706 9498754 1745 41.8% 0 0.0% 4171 41.8% "biological_process; cellular_component; molecular_function" Mcvq5 4930455B14Rik 14 9498904 9505892 25 19.4% 0 0.0% 129 19.4% "biological_process; cellular_component; molecular_function" Mcvq5 Fhit 14 10382606 11994549 12487 44.3% 14 0.0% 28208 44.3% "decreased granulocyte number; alopecia; abnormal small intestine morphology; papilloma; increased tumor incidence; increased lymphoma incidence; B cell derived lymphoma; premature death; increased susceptibility to infection; hepatocellular carcinoma; increased incidence of chemically-induced tumors" "bis(5'-adenosyl)-triphosphatase activity; cytoplasm; DNA replication; hydrolase activity; bis(5'-adenosyl)-triphosphatase activity; cytoplasm; cytosol; diadenosine triphosphate catabolic process; hydrolase activity; intracellular membrane-bounded organelle; nickel ion binding; nucleus; plasma membrane; catalytic activity; nucleotide metabolic process" Mcvq5 Gm16542 14 11571067 11611515 341 51.8% 0 0.0% 658 51.8% "biological_process; cellular_component; molecular_function" Mcvq5 Gm3600 14 11808329 11811148 29 65.9% 0 0.0% 44 65.9% "biological_process; cellular_component; molecular_function" Mcvq5 Ptprg 14 12386046 13074555 5529 42.7% 27 0.2% 12962 42.9% "impaired coordination; abnormal cued conditioning behavior; decreased startle reflex; abnormal fear/anxiety-related behavior; hyperresponsive to tactile stimuli" "hydrolase activity; integral to membrane; membrane; phosphatase activity; phosphoprotein phosphatase activity; protein dephosphorylation; dephosphorylation; extracellular space; identical protein binding; negative regulation of neuron projection development; protein tyrosine phosphatase activity" Mcvq5 Gm3848 14 12797961 12813737 151 51.5% 0 0.0% 293 51.5% "biological_process; cellular_component; molecular_function" Mcvq5 3830406C13Rik 14 13116772 13134492 57 42.2% 0 0.0% 135 42.2% "biological_process; cellular_component; molecular_function" Mcvq5 Gm8443 14 13116780 13117729 4 66.7% 0 0.0% 6 66.7% "biological_process; cellular_component; molecular_function" Mcvq5 Fezf2 14 13174616 13178342 8 38.1% 0 0.0% 21 38.1% "abnormal cerebral cortex morphology; abnormal hippocampus morphology; abnormal dentate gyrus morphology; abnormal diencephalon morphology; abnormal thalamus morphology; abnormal telencephalon development; abnormal stationary movement; hyperactivity; abnormal food preference; postnatal growth retardation; premature death; absent corpus callosum; small olfactory bulb; abnormal axon guidance; abnormal axon morphology; abnormal neocortex morphology" "negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II core promoter proximal region sequence-specific DNA binding; cell differentiation; DNA binding; intracellular; metal ion binding; multicellular organismal development; nervous system development; nucleic acid binding; nucleus; regulation of transcription; transcription; zinc ion binding; forebrain anterior/posterior pattern formation; positive regulation of neuron differentiation; telencephalon development; axon guidance; axonal fasciculation; dendrite development; dentate gyrus development; forebrain development; locomotory behavior" Mcvq5 Cadps 14 13205077 13655593 3324 43.4% 12 0.2% 7654 43.6% "abnormal adrenal gland secretion; respiratory failure; neonatal lethality; abnormal glucose homeostasis; abnormal CNS synaptic transmission; increased glucagon secretion; abnormal neuron morphology; increased insulin sensitivity; abnormal adrenal gland physiology; abnormal excitatory postsynaptic currents; decreased insulin secretion; abnormal lysosome physiology; abnormal pancreatic beta cell physiology; abnormal hormone level; abnormal miniature excitatory postsynaptic currents; abnormal neuron physiology; abnormal pancreatic beta cell morphology; impaired glucose tolerance" "cytoplasmic vesicle; cell junction; lipid binding; membrane; metal ion binding; protein transport; synapse; transport; catecholamine secretion; vesicle organization; protein binding; calcium ion binding; positive regulation of calcium ion-dependent exocytosis" Mcvq5 n-R5s45 14 13260046 13260155 0 - 0 - 0 - Mcvq5 Gm5087 14 13989902 14117152 956 39.4% 0 0.0% 2428 39.4% "biological_process; cellular_component; molecular_function" Mcvq5 Synpr 14 14117294 14447973 3211 47.5% 0 0.0% 6766 47.5% "cell junction; cytoplasmic vesicle; integral to membrane; membrane; synapse; synaptic vesicle; synaptosome; transport; transporter activity; integral to synaptic vesicle membrane" Mcvq5 Sntn 14 14503390 14515662 67 51.9% 0 0.0% 129 51.9% "calcium ion binding; cell projection; cilium; biological_process" Mcvq5 Gm281 14 14647463 14746992 923 47.1% 0 0.0% 1958 47.1% "integral to membrane; membrane; biological_process; molecular_function" Mcvq5 Gm11100 14 14765408 14782072 199 61.4% 0 0.0% 324 61.4% "biological_process; cellular_component; molecular_function" Mcvq5 Thoc7 14 14781528 14793739 106 52.2% 0 0.0% 203 52.2% "cytoplasm; mRNA processing; mRNA transport; RNA binding; RNA splicing; transport; intronless viral mRNA export from host nucleus; mRNA export from nucleus; nucleus; THO complex; THO complex part of transcription export complex; transcription export complex" Mcvq5 Atxn7 14 14845005 14936574 489 51.6% 0 0.0% 948 51.6% "kyphosis; myoclonus; decreased brain size; abnormal cerebellum morphology; abnormal Purkinje cell morphology; abnormal retinal rod cell morphology; decreased retinal photoreceptor cell number; blepharoptosis; ataxia; hypoactivity; impaired coordination; male infertility; female infertility; premature death; decreased post-tetanic potentiation; thin retinal inner plexiform layer; short photoreceptor outer segment" "chromatin binding; cytoplasm; nucleus; intracellular; regulation of transcription; transcription; zinc ion binding; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein binding; cytoplasm; histone deubiquitination; nucleus" Mcvq5 Psmd6 14 14944698 14953498 28 38.4% 0 0.0% 73 38.4% "proteasome complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle" Mcvq5 Olfr720 14 15007644 15008594 2 100.0% 0 0.0% 2 100.0% "G-protein coupled receptor activity; receptor activity; signal transducer activity; signal transduction; G-protein coupled receptor protein signaling pathway; integral to membrane; olfactory receptor activity; sensory perception of smell" Mcvq5 Olfr31 14 15160627 15161580 5 55.6% 0 0.0% 9 55.6% "G-protein coupled receptor activity; receptor activity; signal transducer activity; signal transduction; G-protein coupled receptor protein signaling pathway; integral to membrane; olfactory receptor activity; sensory perception of smell" Mcvq5 Il3ra 14 15179009 15188004 49 28.8% 0 0.0% 170 28.8% "abnormal leukopoiesis; abnormal common myeloid progenitor cell morphology" "cytokine receptor activity; cytokine-mediated signaling pathway; integral to membrane; membrane; receptor activity; signal transduction; plasma membrane" Mcvq5 Gm3694 14 15478294 15522807 299 40.6% 0 0.0% 736 40.6% "biological_process; cellular_component; molecular_function" Mcvq5 Slc4a7 14 15535539 15632457 410 43.6% 0 0.0% 940 43.6% "cochlear degeneration; organ of Corti degeneration; abnormal stria vascularis; decreased retinal photoreceptor cell number; blindness; abnormal retinal vasculature morphology; cochlear ganglion degeneration; abnormal ocular fundus morphology; abnormal rod electrophysiology; abnormal pH regulation; abnormal spiral ligament morphology; abnormal spiral ligament fibrocyte morphology; abnormal type I spiral ligament fibrocytes; cochlear hair cell degeneration; cochlear inner hair cell degeneration; cochlear outer hair cell degeneration; abnormal Claudius cell morphology; degeneration of organ of Corti supporting cells; type II spiral ligament fibrocyte degeneration; type IV spiral ligament fibrocyte degeneration; decreased brainstem auditory evoked potential; collapsed Reissner membrane; abnormal retinal apoptosis; retinal photoreceptor degeneration; thin retinal outer nuclear layer; photoreceptor outer segment degeneration; short photoreceptor outer segment" "apical plasma membrane; basolateral plasma membrane; cytoplasm; anion transmembrane transporter activity; anion transport; cell projection; inorganic anion exchanger activity; integral to membrane; ion transmembrane transport; ion transport; membrane; plasma membrane; sodium ion transport; symporter activity; transmembrane transport; transport; transporter activity; apical plasma membrane; basolateral plasma membrane; cytoplasmic vesicle" Mcvq5 Nek10 14 15653279 15839445 1428 36.3% 0 0.0% 3930 36.3% "ATP binding; binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity; cellular_component" Mcvq5 Lrrc3b 14 16190034 16271387 576 38.5% 0 0.0% 1498 38.5% "integral to membrane; membrane" Mcvq5 Gm10403 14 16288845 16290555 15 36.6% 0 0.0% 41 36.6% "biological_process; cellular_component; molecular_function" Mcvq5 1700062C10Rik 14 16833312 16869785 379 46.1% 0 0.0% 823 46.1% "biological_process; cellular_component; molecular_function" Mcvq5 Oxsm 14 17071170 17082322 36 35.6% 0 0.0% 101 35.6% "mitochondrion; acyltransferase activity; biosynthetic process; catalytic activity; fatty acid biosynthetic process; lipid biosynthetic process; metabolic process; transferase activity; transferase activity, transferring acyl groups other than amino-acyl groups; 3-oxoacyl-[acyl-carrier-protein] synthase activity; acyl-CoA metabolic process; cytoplasm; medium-chain fatty acid biosynthetic process; mitochondrion; short-chain fatty acid biosynthetic process" Mcvq5 Ngly1 14 17081809 17144440 232 38.2% 0 0.0% 607 38.2% "cytoplasm; glycoprotein catabolic process; hydrolase activity; metal ion binding; protein binding; cytoplasm; glycoprotein catabolic process; nucleus; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity" Mcvq5 Top2b 14 17197693 17263301 293 50.8% 0 0.0% 577 50.8% "kyphosis; paralysis; decreased brain size; abnormal cerebral cortex morphology; abnormal stratification in cerebral cortex; abnormal hippocampus morphology; abnormal telencephalon development; abnormal motor neuron innervation; abnormal muscle innervation; atelectasis; decreased body size; decreased embryo size; respiratory failure; neonatal lethality; abnormal motor capabilities/coordination/movement; no abnormal phenotype detected; small olfactory bulb; abnormal spine curvature; abnormal embryonic/fetal subventricular zone morphology; abnormal neuronal migration; abnormal hippocampus pyramidal cell layer; abnormal hippocampus granule cell layer; disorganized cortical plate; absent subplate" "nucleus; ATP binding; DNA binding; DNA metabolic process; DNA topoisomerase activity; isomerase activity; nucleotide binding; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; axonogenesis; forebrain development; neuron migration; chromatin binding; cytosol; histone deacetylase binding; nucleoplasm; nucleus; protein C-terminus binding; protein heterodimerization activity; protein kinase C binding; WINAC complex; chromatin binding; DNA topoisomerase (ATP-hydrolyzing) activity; DNA topoisomerase complex (ATP-hydrolyzing); DNA topological change; DNA-dependent ATPase activity; DNA-dependent DNA replication; histone deacetylase binding; mitotic cell cycle G2/M transition decatenation checkpoint; mitotic recombination; protein kinase C binding; resolution of meiotic recombination intermediates; sister chromatid segregation; synaptonemal complex; WINAC complex" Mcvq5 Rarb 14 17263353 17407724 1270 47.5% 1 0.0% 2671 47.6% "abnormal basioccipital bone morphology; abnormal vertebrae morphology; abnormal sternum morphology; abnormal xiphoid process; abnormal cartilage morphology; abnormal esophageal epithelium morphology; abnormal stomach epithelium morphology; abnormal pulmonary artery morphology; hydronephrosis; abnormal kidney cortex; abnormal ureter morphology; hydroureter; abnormal parathyroid gland morphology; abnormal thymus morphology; abnormal hypoglossal nerve morphology; abnormal female reproductive system morphology; abnormal vagina morphology; abnormal lung morphology; pulmonary hypoplasia; absent lungs; decreased body weight; abnormal eye development; persistence of hyaloid vascular system; abnormal lens morphology; cataracts; abnormal conjunctiva morphology; abnormal retina morphology; abnormal spatial learning; reduced long term potentiation; postnatal growth retardation; absent long term depression; perinatal lethality; abnormal embryonic tissue morphology; abnormal cardiovascular system morphology; abnormal respiratory system morphology; no abnormal phenotype detected; ectopia; abnormal artery morphology; abnormal arytenoid cartilage morphology; abnormal cricoid cartilage morphology; abnormal thyroid cartilage morphology; abnormal bronchus morphology; abnormal left major bronchus morphology; abnormal right major bronchus morphology; abnormal trachea morphology; persistent truncus arteriosis; abnormal branchial arch artery morphology; abnormal sclera morphology; abnormal vitreous body; abnormal renal tubule morphology; abnormal aortic valve morphology; abnormal lens fiber morphology; abnormal branchial arch morphology; abnormal excitatory postsynaptic potential; vertebral transformation; abnormal tracheal-esophageal septation; abnormal tracheal cartilage morphology; renal hypoplasia; absent uterus; absent oviduct; single kidney; herniated diaphragm; abnormal periocular mesenchyme morphology; right aortic arch; abnormal squamosal bone morphology; abnormal vertebral arch morphology; fusion of vertebral arches; cervical vertebral transformation; lumbar vertebral transformation; thoracic vertebral transformation; absent stapedial artery; split vertebrae; abnormal incus morphology; abnormal stapes morphology; abnormal eye anterior chamber; abnormal iris stroma morphology; narrow eye opening; abnormal corneal stroma morphology; abnormal renal glomerulus morphology; abnormal skeleton morphology; abnormal inferior vena cava morphology; abnormal retinal neuronal layer morphology; vitreous body deposition; absent Mullerian ducts; abnormal gonial bone morphology; absent retinal inner plexiform layer; abnormal interventricular septum membranous part morphology; absent Harderian gland; abnormal nasolacrimal duct morphology; ethmoturbinate hypoplasia; absent anal canal; absent cranial vagina; rudimentary Mullerian ducts; abnormal sublingual duct morphology; ventricular septal defect; perimembraneous ventricular septal defect; absent fetal ductus arteriosus; persistent right dorsal aorta; abnormal conotruncus septation; fusion of atlas and odontoid process; split cervical atlas; split cervical axis; absent metoptic pilar; persistent hyperplastic primary vitreous; coloboma of the iris; coloboma of the optic disc; fusion of atlas and occipital bones" "negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription activator activity; DNA binding; ligand-dependent nuclear receptor activity; metal ion binding; receptor activity; regulation of transcription; regulation of transcription, DNA-dependent; retinoic acid receptor activity; retinoic acid receptor signaling pathway; signal transduction; steroid hormone mediated signaling pathway; steroid hormone receptor activity; transcription; zinc ion binding; embryonic eye morphogenesis; embryonic hindlimb morphogenesis; growth plate cartilage development; multicellular organism growth; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of programmed cell death; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cartilage development; negative regulation of chondrocyte differentiation; neurogenesis; striatum development; ureteric bud development; ventricular cardiac muscle cell differentiation; protein binding; nucleus" Mcvq5 Thrb 14 18493474 18870600 2388 43.7% 1 0.0% 5465 43.7% "abnormal cochlea morphology; abnormal organ of Corti; organ of Corti degeneration; osteoporosis; premature suture closure; abnormal fontanelle morphology; abnormal cancellous bone morphology; decreased cortical bone thickness; abnormal long bone hypertrophic chondrocyte zone; abnormal cranium morphology; delayed intestine development; abnormal small intestine morphology; short limbs; short tail; enlarged pituitary gland; small cerebellum; abnormal cerebellar Purkinje cell layer; abnormal Purkinje cell morphology; decreased Purkinje cell number; thin cerebellar molecular layer; abnormal retinal cone cell morphology; decreased body length; decreased body weight; decreased body size; abnormal spatial learning; audiogenic seizures; abnormal osteoclast physiology; abnormal postnatal growth; postnatal growth retardation; female infertility; respiratory distress; deafness; increased pituitary adenoma incidence; postnatal lethality; premature death; abnormal limb morphology; abnormal skeleton development; increased heart rate; abnormal sperm motility; short tibia; abnormal thyroid physiology; abnormal bone mineralization; abnormal long bone epiphyseal plate morphology; short femur; abnormal tectorial membrane morphology; detached tectorial membrane; premature endochondral bone ossification; premature intramembranous bone ossification; thyroid gland hyperplasia; increased activity of thyroid; abnormal response/metabolism to endogenous compounds; abnormal long bone epiphyseal plate proliferative zone; abnormal bone structure; abnormal pillar cell morphology; abnormal pituitary hormone level; abnormal cone electrophysiology; abnormal cardiac cell glucose uptake; increased cortical bone thickness; abnormal fetal growth/weight/body size; cochlear hair cell degeneration; decreased cochlear outer hair cell number; cochlear outer hair cell degeneration; decreased endocochlear potential; decreased cochlear microphonics; abnormal cochlear nerve compound action potential; abnormal cochlear inner hair cell physiology; abnormal cochlear outer hair cell physiology; decreased cochlear outer hair cell electromotility; degeneration of organ of Corti supporting cells; short cochlear outer hair cells; enlarged tectorial membrane; delayed inner ear development; abnormal thyroid follicle morphology; decreased circulating insulin-like growth factor I level; abnormal distortion product otoacoustic emission; absent distortion product otoacoustic emissions; sensorineural hearing loss; decreased brainstem auditory evoked potential; decreased testis weight; spiral ligament degeneration; increased osteoclast cell number; increased circulating thyroid-stimulating hormone level; decreased follicle stimulating hormone level; decreased luteinizing hormone level; increased thyroid-stimulating hormone level; decreased growth hormone level; decreased prolactin level; enlarged thyroid gland; small pituitary gland; abnormal circulating hormone level; abnormal thyroid hormone level; increased thyroxine level; increased triiodothyronine level; increased circulating thyroxine level; decreased circulating thyroxine level; decreased circulating triiodothyronine level; increased circulating triiodothyronine level; abnormal pituitary gland physiology; impaired hearing; abnormal epiphyseal plate morphology; decreased long bone epiphyseal plate size; decreased small intestinal villus size; increased thyrotroph cell number; decreased cancellous bone thickness; increased sensitivity to xenobiotic induced morbidity/mortality; abnormal chondrocyte physiology; increased thyroid carcinioma incidence" "negative regulation of transcription; transcription repressor activity; DNA binding; ligand-dependent nuclear receptor activity; metal ion binding; receptor activity; regulation of transcription; sequence-specific DNA binding; signal transduction; steroid hormone mediated signaling pathway; steroid hormone receptor activity; transcription; zinc ion binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription repressor activity; female courtship behavior; negative regulation of female receptivity; organ morphogenesis; regulation of heart contraction; sensory perception of sound; protein binding; double-stranded DNA binding; enzyme binding; positive regulation of cell proliferation; positive regulation of chondrocyte differentiation; positive regulation of ossification; protein homodimerization activity; regulation of cholesterol metabolic process; regulation of lipid metabolic process; regulation of triglyceride metabolic process; signal transduction; thyroid hormone receptor activity; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; thyroid hormone receptor activity" Mcvq5 Nr1d2 14 19036568 19071641 105 37.5% 0 0.0% 280 37.5% "DNA binding; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; ligand-dependent nuclear receptor activity; metal ion binding; nucleus; receptor activity; regulation of transcription; sequence-specific DNA binding; signal transduction; steroid hormone mediated signaling pathway; steroid hormone receptor activity; thyroid hormone receptor activity; transcription; zinc ion binding" Mcvq5 Rpl15 14 19100337 19103905 17 53.1% 0 0.0% 32 53.1% "cytosol; translational elongation; molecular_function; biological_process; cellular_component; molecular_function; biological_process; cellular_component; molecular_function; biological_process; cellular_component; molecular_function" Mcvq5 Nkiras1 14 19103650 19116456 53 39.0% 0 0.0% 136 39.0% "cytoplasm; GTP binding; nucleotide binding; small GTPase mediated signal transduction" Mcvq5 Ube2e1 14 19115236 19164373 151 31.3% 0 0.0% 482 31.3% "acid-amino acid ligase activity; ATP binding; ligase activity; nucleotide binding; post-translational protein modification; protein binding; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol; histone H2B ubiquitination; histone monoubiquitination; ISG15 ligase activity; ISG15-protein conjugation; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; nucleus; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; protein K48-linked ubiquitination; protein polyubiquitination; protein ubiquitination; ubiquitin ligase complex; ubiquitin-protein ligase activity" Mcvq5 Ube2e2 14 19406091 19726781 1096 40.0% 0 0.0% 2742 40.0% "acid-amino acid ligase activity; ATP binding; ligase activity; nucleotide binding; post-translational protein modification; ISG15 ligase activity; ISG15-protein conjugation; nucleolus; protein K11-linked ubiquitination; protein K48-linked ubiquitination; protein K63-linked ubiquitination; ubiquitin-protein ligase activity" Mcvq5 Gm3789 14 19875616 19875951 0 0.0% 0 0.0% 3 0.0% "biological_process; cellular_component; molecular_function" Mcvq5 Gm7088 14 19912225 19919852 30 38.0% 0 0.0% 79 38.0% "biological_process; cellular_component; molecular_function" Mcvq5 Gm2244 14 20352116 20369238 5 100.0% 0 0.0% 5 100.0% "biological_process; cellular_component; molecular_function" Mcvq5 Gm5458 14 20413382 20421792 28 63.6% 0 0.0% 44 63.6% "biological_process; cellular_component; molecular_function" Mcvq5 4930469B13Rik 14 20434352 20436596 17 94.4% 0 0.0% 18 94.4% "biological_process; cellular_component; molecular_function" Mcvq5 Nid2 14 20570479 20631009 1116 98.2% 0 0.0% 1136 98.2% "no abnormal phenotype detected; abnormal cell physiology" "basement membrane; cell-matrix adhesion; proteinaceous extracellular matrix; bioluminescence; calcium ion binding; cell adhesion; extracellular region; membrane; protein-chromophore linkage; basement membrane; cell-matrix adhesion; protein binding" Mcvq5 2700060E02Rik 14 20631143 20643020 97 99.0% 1 1.0% 98 100.0% "cytoplasm; cytoskeleton; nucleus; identical protein binding" Mcvq5 Gm2295 14 20658147 20663899 111 100.0% 0 0.0% 111 100.0% "biological_process; cellular_component; molecular_function" Mcvq5 Gng2 14 20691781 20796849 1756 99.3% 6 0.3% 1768 99.7% "plasma membrane; cell proliferation; G-protein coupled receptor protein signaling pathway; membrane; signal transducer activity; signal transduction; cellular response to glucagon stimulus; G-protein coupled receptor protein signaling pathway; GTPase activity; heterotrimeric G-protein complex; plasma membrane" Mcvq5 1810063B07Rik 14 20894882 20902320 108 100.0% 0 0.0% 108 100.0% "integral to membrane; membrane; biological_process; molecular_function" Mcvq5 Kcnk5 14 20959280 21001004 464 99.6% 1 0.2% 466 99.8% "decreased body weight; abnormal respiration; prenatal lethality; abnormal nervous system physiology; abnormal brainstem morphology; abnormal kidney excretion; abnormal kidney clearance; natriuresis" "integral to membrane; ion channel activity; ion transmembrane transport; ion transport; membrane; transport" Mcvq5 Kcnk16 14 21081978 21088384 149 100.0% 0 0.0% 149 100.0% "potassium channel activity; potassium ion transmembrane transport; potassium ion transport; cellular_component" Mcvq5 Nudt13 14 21113912 21136797 552 99.5% 3 0.5% 555 100.0% "mitochondrion; hydrolase activity; metabolic process; metal ion binding" Mcvq5 Ecd 14 21139361 21167306 372 100.0% 0 0.0% 372 100.0% postnatal lethality "double-strand break repair via homologous recombination; protein binding; peptidase activity; proteasome complex; proteolysis; cytoplasm; nucleus; regulation of transcription; transcription" Mcvq5 Fam149b 14 21167384 21202711 313 99.4% 1 0.3% 315 99.7% "biological_process; cellular_component; molecular_function" Mcvq5 Dnajc9 14 21204087 21208094 21 100.0% 0 0.0% 21 100.0% "heat shock protein binding; protein folding; unfolded protein binding; cellular_component" Mcvq5 Mrps16 14 21210453 21212777 25 100.0% 0 0.0% 25 100.0% "mitochondrion; intracellular; ribonucleoprotein complex; ribosome; structural constituent of ribosome; translation; mitochondrial small ribosomal subunit" Mcvq5 Ttc18 14 21213415 21271448 1070 95.6% 28 2.5% 1119 98.1% "biological_process; cellular_component; molecular_function" Mcvq5 7330404K18Rik 14 21217581 21218152 9 100.0% 0 0.0% 9 100.0% "biological_process; cellular_component; molecular_function" Mcvq5 Anxa7 14 21275392 21299154 240 96.0% 10 4.0% 250 100.0% "increased body weight; increased body size; abnormal cardiovascular system physiology; abnormal ion homeostasis; pancreas inflammation; intraventricular hemorrhage; increased tumor incidence; increased lymphoma incidence; abnormal erythrocyte morphology; increased growth rate; decreased insulin secretion; hepatocellular carcinoma; abnormal pancreatic beta cell physiology; abnormal glial cell physiology; chromosome breakage; abnormal pancreatic beta cell morphology; pancreatic islet hyperplasia; increased platelet cell number; embryonic lethality during organogenesis; enlarged pancreatic islets; abnormal platelet aggregation" "cytosol; insoluble fraction; nuclear envelope; nucleus; plasma membrane; soluble fraction; vesicle; calcium ion binding; cell proliferation; cellular calcium ion homeostasis; cellular water homeostasis; hemostasis; regulation of cell shape; response to salt stress; protein binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; cellular membrane fusion; response to calcium ion; response to organic cyclic substance" Mcvq5 Zmynd17 14 21302138 21316016 156 95.7% 5 3.1% 163 98.8% "metal ion binding; zinc ion binding; biological_process; cellular_component" Mcvq5 Ppp3cb 14 21318586 21365795 253 92.7% 16 5.9% 273 98.5% "decreased body weight; hyperactivity; thymus hypoplasia; abnormal T cell differentiation; small heart; abnormal CD4-positive T cell morphology; abnormal cytokine secretion; decreased response of heart to induced stress; decreased thymus weight; abnormal CD8-positive T cell morphology; decreased T cell number; decreased T cell proliferation; decreased susceptibility to injury; abnormal CD4-positive T cell physiology; decreased single-positive T cell number; decreased skeletal muscle fiber diameter; increased skeletal muscle fiber number; abnormal skeletal muscle fiber type ratio" "protein serine/threonine phosphatase activity; dephosphorylation; hydrolase activity; metabolic process; metal ion binding; phosphoprotein phosphatase activity; heart development; negative regulation of T cell mediated cytotoxicity; protein dephosphorylation; regulation of gene expression; response to cytokine stimulus; T cell differentiation; T cell homeostasis; calcium-dependent protein serine/threonine phosphatase activity; calmodulin binding; insoluble fraction; protein complex; protein dephosphorylation; protein heterodimerization activity; soluble fraction" Mcvq5 1810062O18Rik 14 21365301 21389909 167 98.2% 3 1.8% 170 100.0% "biological_process; cellular_component; molecular_function" Mcvq5 Usp54 14 21368134 21437576 496 95.8% 14 2.7% 518 98.5% "ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; cellular_component" Mcvq5 Myoz1 14 21468330 21475717 94 98.9% 1 1.1% 95 100.0% "muscle degeneration; abnormal muscle regeneration; abnormal skeletal muscle morphology; decreased body weight; abnormal muscle physiology; abnormal exercise endurance; abnormal gastrocnemius morphology; abnormal locomotor activation; abnormal muscle tone; decreased skeletal muscle fiber size; increased skeletal muscle fiber diameter; abnormal skeletal muscle fiber type ratio; decreased gastrocnemius weight" "actin cytoskeleton; cell projection; nucleus; actin cytoskeleton; protein binding; FATZ binding" Mcvq5 Synpo2l 14 21478168 21487576 78 97.5% 1 1.3% 80 98.8% "actin binding; cytoplasm; cytoskeleton; biological_process" Mcvq5 Sec24c 14 21493565 21514070 154 96.9% 4 2.5% 159 99.4% "protein transport; transport; protein binding; cellular membrane organization; ER to Golgi vesicle-mediated transport" Mcvq5 6230400D17Rik 14 21506458 21522234 173 96.6% 6 3.4% 179 100.0% "biological_process; cellular_component; molecular_function" Mcvq5 Fut11 14 21514190 21519419 71 93.4% 5 6.6% 76 100.0% "alpha(1,3)-fucosyltransferase activity; fucosyltransferase activity; Golgi apparatus; Golgi membrane; integral to membrane; membrane; protein glycosylation; transferase activity; transferase activity, transferring glycosyl groups" Mcvq5 Chchd1 14 21522291 21523639 18 81.8% 0 0.0% 22 81.8% "mitochondrion; nucleus; biological_process; molecular_function" Mcvq5 2310021P13Rik 14 21526774 21542840 130 97.7% 2 1.5% 133 99.2% "metal ion binding; zinc ion binding; biological_process; cellular_component" Mcvq5 Ndst2 14 21542952 21549702 35 94.6% 2 5.4% 37 100.0% "decreased mast cell number; abnormal mast cell morphology; decreased mast cell protease storage; decreased mast cell histamine storage; prenatal lethality; decreased susceptibility to induced arthritis; abnormal response to infection; decreased mast cell degranulation" "Golgi apparatus; catalytic activity; hydrolase activity; integral to membrane; membrane; metabolic process; sulfotransferase activity; transferase activity; cellular process; heparan sulfate proteoglycan biosynthetic process; [heparan sulfate]-glucosamine N-sulfotransferase activity; glycosaminoglycan biosynthetic process" Mcvq5 Camk2g 14 21554105 21613252 440 99.5% 1 0.2% 442 99.8% "female infertility; abnormal macrophage physiology; decreased susceptibility to injury" "ATP binding; calmodulin binding; kinase activity; nucleotide binding; protein kinase activity; protein phosphorylation; transferase activity; calcium ion transport; G1/S transition of mitotic cell cycle; protein autophosphorylation; protein serine/threonine kinase activity; calmodulin-dependent protein kinase activity; cytosol; endocytic vesicle membrane; nucleoplasm; plasma membrane; protein autophosphorylation; response to hypoxia; response to oxidative stress" Mcvq5 Plau 14 21655929 21662610 79 98.8% 1 1.3% 80 100.0% "abnormal rectum morphology; rectal prolapse; abnormal muscle regeneration; myopathy; decreased body weight; decreased body size; decreased metastatic potential; abnormal eyelid morphology; necrosis; postnatal growth retardation; increased inflammatory response; liver inflammation; decreased inflammatory response; reduced fertility; decreased litter size; respiratory distress; carcinoma; premature death; abnormal outer ear morphology; abnormal trachea morphology; abnormal cell-mediated immunity; abnormal macrophage physiology; abnormal neutrophil physiology; impaired neutrophil phagocytosis; chronic inflammation; heart left ventricle hypertrophy; aortic elastic tissue lesions; abnormal perineum morphology; liver fibrosis; reduced thrombolysis; pulmonary interstitial fibrosis; increased resistance to induced choroidal neovascularization; herniated seminal vesicle; decreased susceptibility to induced arthritis; decreased tumor growth/size; altered tumor morphology; increased lymphocyte cell number; increased susceptibility to parasitic infection; thrombosis; impaired granulocyte bactericidal activity; decreased T cell proliferation; cachexia; abnormal response to injury; decreased susceptibility to atherosclerosis; increased susceptibility to fungal infection; abnormal circulating protein level; impaired macrophage recruitment; increased ventricle muscle contractility; cardiac interstitial fibrosis; abnormal cytokine level; embryonic lethality; decreased physiological sensitivity to xenobiotic; decreased total body fat amount; abnormal acute phase protein level; decreased liver glycogen level" "catalytic activity; extracellular region; hydrolase activity; kinase activity; peptidase activity; phosphorylation; proteolysis; serine-type endopeptidase activity; serine-type peptidase activity; regulation of cell proliferation; response to hypoxia; smooth muscle cell migration; angiogenesis; cell surface; extracellular space; plasma membrane; regulation of cell adhesion mediated by integrin; regulation of receptor activity; regulation of smooth muscle cell migration; regulation of smooth muscle cell-matrix adhesion; skeletal muscle tissue regeneration; wound healing" Mcvq5 Vcl 14 21748655 21852895 1163 98.1% 15 1.3% 1186 99.3% "abnormal heart development; abnormal myocardial fiber morphology; abnormal heart valve morphology; enlarged pericardium; absent atrioventricular cushions; abnormal head morphology; abnormal foregut morphology; decreased brain size; abnormal brain ventricle morphology; exencephaly; incomplete cephalic closure; wavy neural tube; small dorsal root ganglion; abnormal cranial nerve morphology; abnormal spinal nerve morphology; abnormal cardiovascular system physiology; cardiac hypertrophy; abnormal heart rate; irregular heartbeat; abnormal ectoderm development; abnormal mesoderm development; failure of somite differentiation; decreased embryo size; embryonic growth arrest; premature death; abnormal cardiovascular system morphology; small heart; thin myocardium; dilated heart left ventricle; dilated cardiomyopathy; increased heart weight; abnormal cell migration; abnormal impulse conducting system conduction; cardiac fibrosis; abnormal cell adhesion; abnormal neural tube closure; abnormal craniofacial development; embryonic growth retardation; abnormal cardiac muscle relaxation; abnormal embryonic neuroepithelium morphology; decreased myocardial fiber number; small limb buds; abnormal neural fold formation; dilated vasculature; decreased cardiac muscle contractility; abnormal rostral-caudal axis patterning; abnormal somite size; decreased ventricle muscle contractility; abnormal limb bud morphology; increased apoptosis; abnormal heart position or orientation; congestive heart failure; embryonic lethality during organogenesis; abnormal intercalated disc morphology; abnormal mesenchyme morphology; abnormal embryonic tissue physiology; ventricular tachycardia; increased sensitivity to induced morbidity/mortality; prolonged QRS complex duration; abnormal heart electrocardiography waveform feature" "adherens junction; cell adhesion; cell-cell junction; costamere; fascia adherens; focal adhesion; lamellipodium assembly; plasma membrane; regulation of cell migration; actin binding; actin cytoskeleton; cell junction; cytoplasm; cytoskeleton; membrane; structural molecule activity; protein binding; actin filament; adherens junction assembly; alpha-catenin binding; apical junction assembly; beta-dystroglycan binding; cell-cell adherens junction; costamere; cytosol; epithelial cell-cell adhesion; extracellular region; focal adhesion; morphogenesis of an epithelium; muscle contraction; protein complex; protein localization at cell surface; Rho GTPase binding; stress fiber" Mcvq5 Gm11098 14 21829728 21830521 3 100.0% 0 0.0% 3 100.0% "biological_process; cellular_component; molecular_function" Mcvq5 Ap3m1 14 21850664 21871730 274 98.2% 1 0.4% 279 98.6% "clathrin adaptor complex; Golgi apparatus; intracellular protein transport; protein transport; transport; vesicle-mediated transport; molecular_function" Mcvq5 Adk 14 21871861 22267764 6194 96.1% 170 2.6% 6443 98.8% "pale liver; decreased body weight; decreased body size; delayed eyelid opening; postnatal growth retardation; abnormal homeostasis; abnormal body temperature regulation; apnea; postnatal lethality; hepatic steatosis; abnormal nucleotide metabolism" "adenosine kinase activity; cytosol; nucleus; purine ribonucleoside salvage; ATP binding; kinase activity; metabolic process; metal ion binding; nucleotide binding; phosphorylation; phosphotransferase activity, alcohol group as acceptor; transferase activity; dATP biosynthetic process; adenosine kinase activity; adenosine metabolic process; phosphorylation; positive regulation of T cell proliferation" Mcvq5 Myst4 14 22319076 22491354 3138 97.8% 33 1.0% 3210 98.8% "abnormal ear distance/ position; abnormal parietal bone morphology; shortened head; abnormal cranium morphology; decreased brain size; abnormal cerebral cortex morphology; abnormal telencephalon development; decreased body weight; decreased body size; microphthalmia; postnatal growth retardation; postnatal lethality; small olfactory bulb; abnormal cranial suture morphology; abnormal coronal suture morphology; abnormal occipital bone morphology; abnormal nasolacrimal duct morphology; decreased inferior colliculus size" "histone acetylation; histone acetyltransferase activity; acyltransferase activity; chromatin modification; DNA binding; metal ion binding; nucleosome; nucleosome assembly; regulation of transcription; transcription; transferase activity; transferase activity, transferring acyl groups other than amino-acyl groups; zinc ion binding; acetyltransferase activity; histone acetylation; histone acetyltransferase activity; histone H3 acetylation; MOZ/MORF histone acetyltransferase complex; negative regulation of transcription; nucleus; positive regulation of transcription; transcription activator activity; transcription factor binding; transcription repressor activity" Mcvq5 Dupd1 14 22495804 22533798 686 97.3% 12 1.7% 705 99.0% "cytoplasm; dephosphorylation; hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity; protein dephosphorylation; protein tyrosine/serine/threonine phosphatase activity" Mcvq5 Dusp13 14 22552617 22570403 212 98.6% 1 0.5% 215 99.1% "protein tyrosine/serine/threonine phosphatase activity; dephosphorylation; hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity; cytoplasm; protein dephosphorylation" Mcvq5 Gm15935 14 22560765 22565854 72 100.0% 0 0.0% 72 100.0% "biological_process; cellular_component; molecular_function" Mcvq5 Samd8 14 22569753 22617947 581 94.3% 7 1.1% 616 95.5% "lipid metabolic process; membrane; sphingolipid metabolic process; integral to membrane; sphingomyelin biosynthetic process; molecular_function" Mcvq5 Vdac2 14 22650493 22665101 175 93.6% 2 1.1% 187 94.7% "mitochondrial inner membrane; mitochondrion; anion transport; integral to membrane; ion transport; membrane; mitochondrial outer membrane; nucleotide binding; pore complex; porin activity; regulation of anion transport; regulation of ion transmembrane transport; transmembrane transport; transport; voltage-gated anion channel activity; mitochondrial nucleoid" Mcvq5 Comtd1 14 22665083 22668199 31 96.9% 1 3.1% 32 100.0% "mitochondrion; integral to membrane; membrane; metabolic process; methylation; methyltransferase activity; O-methyltransferase activity; transferase activity" Mcvq5 Zfp503 14 22803185 22808823 29 87.9% 4 12.1% 33 100.0% "intracellular; metal ion binding; nucleic acid binding; nucleus; regulation of transcription; transcription; zinc ion binding" Mcvq5 1700112E06Rik 14 22838934 23875307 601 96.8% 14 2.3% 621 99.0% "biological_process; cellular_component; molecular_function" Mcvq5 Gm7480 14 22851305 22855325 59 98.3% 1 1.7% 60 100.0% "biological_process; cellular_component; molecular_function" Wbcq7 Ccdc68 18 70085080 70129138 891 90.4% 0 0.0% 986 90.4% "biological_process, cellular_component, molecular_function" Wbcq7 1700061H18Rik 18 70102974 70129263 496 87.6% 0 0.0% 566 87.6% "biological_process, cellular_component, molecular_function" Wbcq7 4930448D08Rik 18 70129331 70132020 30 81.1% 0 0.0% 37 81.1% "biological_process, cellular_component, molecular_function" Wbcq7 Rab27b 18 70138785 70301259 2693 83.2% 0 0.0% 3235 83.2% "diluted coat color, abnormal reproductive system physiology, no abnormal phenotype detected, abnormal blood coagulation, abnormal platelet dense granule number, decreased platelet serotonin level, abnormal corticotroph morphology, abnormal platelet dense granule physiology, decreased platelet aggregation" "Golgi apparatus, GTP binding, GTP catabolic process, GTPase activity, membrane, nucleotide binding, protein transport, small GTPase mediated signal transduction, protein binding, cytoplasm, Golgi apparatus, plasma membrane, regulation of exocytosis, zymogen granule membrane" Wbcq7 2310002L13Rik 18 70400083 70404052 39 30.0% 0 0.0% 130 30.0% "biological_process, cellular_component, molecular_function" Wbcq7 4930503L19Rik 18 70612794 70632134 379 84.8% 0 0.0% 447 84.8% Lung adenoma susceptability extracellular region Wbcq7 Stard6 18 70632199 70660717 225 50.6% 0 0.0% 445 50.6% "Cholesterol Homeostasis, Testis Specific Expression, Obesity Resistant" "cholesterol binding, biological_process, cellular_component" Wbcq7 Poli 18 70668334 70690274 206 71.3% 0 0.0% 289 71.3% "increased incidence of induced tumors, abnormal B cell physiology" "DNA-directed DNA polymerase activity, damaged DNA binding, DNA binding, DNA repair, DNA replication, metal ion binding, nucleotidyltransferase activity, response to DNA damage stimulus, transferase activity, intracellular, intracellular membrane-bounded organelle, nucleus" Wbcq7 Mbd2 18 70727843 70785785 371 72.3% 4 0.8% 513 73.1% "abnormal pup retrieval, abnormal maternal nurturing, decreased litter size, decreased tumor incidence, abnormal motor capabilities/coordination/movement, prenatal lethality, premature death, decreased tumor growth/size" "Chromatin, chromatin binding, cytoplasm, DNA binding, heterochromatin, histone deacetylase complex, methyl-CpG binding, ; mRNA binding, nucleus, siRNA binding, ; regulation of transcription, transcription, positive regulation of Wnt receptor signaling pathway, regulation of cell proliferation, cellular protein complex assembly, maternal behavior, negative regulation of transcription from RNA polymerase II promoter, C2H2 zinc finger domain binding, methyl-CpG binding, nucleus, protein domain specific binding, exopeptidase activity, anchored to membrane, dipeptidase activity, dipeptidyl-peptidase activity, hydrolase activity, membrane, metal ion binding, metalloexopeptidase activity, metallopeptidase activity, peptidase activity, proteolysis" Wbcq7 Dcc 18 71418392 72510723 18683 89.6% 67 0.3% 20863 89.9% "abnormal pons morphology, abnormal optic nerve morphology, abnormal optic nerve innervation, ataxia, abnormal gait, abnormal suckling behavior, respiratory distress, neonatal lethality, absent corpus callosum, increased intestinal adenoma incidence, abnormal corticospinal tract morphology, abnormal axon guidance, abnormal retinal pigmentation, absent hippocampal commissure, increased resistance to dystrophic cardiac calcinosis, increased susceptibility to dystrophic cardiac calcinosis" "plasma membrane, axon, apoptosis, integral to membrane, membrane, multicellular organismal development, receptor activity, signal transduction, dorsal/ventral axon guidance, neuron migration, spinal cord ventral commissure morphogenesis, protein binding, axon, axon guidance, growth cone membrane, membrane raft, netrin receptor activity, plasma membrane, positive regulation of ERK1 and ERK2 cascade, positive regulation of neuron projection development, positive regulation of transcription, transcription coactivator activity, " Wbcq7 Gm4422 18 73070187 73080742 191 84.5% 0 0.0% 226 84.5% "biological_process, cellular_component, molecular_function" Wbcq7 n-R5-8s1 18 73693057 73693204 3 37.5% 0 0.0% 8 37.5% Wbcq7 Mex3c 18 73732698 73752229 188 97.4% 0 0.0% 193 97.4% "Cytoplasm, metal ion binding, nucleus, RNA binding, zinc ion binding, biological_process" Wbcq7 Smad4 18 73798663 73863434 442 98.7% 0 0.0% 448 98.7% "absent atrioventricular cushions, decreased cell proliferation, abnormal hair follicle morphology, enlarged hair follicles, alopecia, abnormal stomach glandular epithelium morphology, abnormal large intestine morphology, abnormal cecum morphology, abnormal small intestine morphology, abnormal kidney development, hydroureter, enlarged liver, enlarged spleen, small thymus, decreased Purkinje cell number, abnormal cerebellar molecular layer, abnormal ovarian folliculogenesis, abnormal ovarian follicle morphology, thick skin, thickened epidermis, hyperkeratosis, anemia, abnormal embryogenesis/ development, absent mesoderm, abnormal endoderm development, abnormal somite development, failure of primitive streak formation, failure to form egg cylinders, failure to gastrulate, decreased embryo size, abnormal dorsal-ventral axis patterning, abnormal proximal-distal axis patterning, abnormal extraembryonic endoderm formation, abnormal allantois morphology, embryonic growth arrest, mammary adenocarcinoma, infertility, decreased litter size, epithelioid cysts, increased tumor incidence, carcinoma, skin papilloma, decreased tumor incidence, abnormal skin morphology, prenatal lethality, perinatal lethality, postnatal lethality, premature death, abnormal extraembryonic tissue morphology, no abnormal phenotype detected, increased intestinal adenoma incidence, increased vertical activity, small ectoplacental cone, hepatic steatosis, abnormal keratinocyte morphology, decreased mature ovarian follicle number, abnormal inner cell mass, abnormal renal corpuscle morphology, abnormal bile duct morphology, intestinal adenocarcinoma, increased liver weight, small kidney, abnormal vitelline vasculature morphology, colon polyps, abnormal duodenum morphology, gastric polyps, pancreas cysts, decreased ovulation rate, abnormal embryonic hematopoiesis, epidermal cyst, decreased tumor growth/size, abnormal keratinocyte physiology, kidney cysts, abnormal hypodermis morphology, abnormal thymus physiology, abnormal hair follicle regression, abnormal embryonic epiblast morphology, abnormal embryonic-extraembryonic boundary morphology, abnormal Reichert's membrane, embryonic growth retardation, abnormal trabecula carnea morphology, abnormal kidney collecting duct, increased circulating progesterone level, disorganized gastric mucosa, abnormal rostral-caudal axis patterning, decreased oocyte cell number, stomach epithelial hyperplasia, abnormal hindbrain development, embryonic lethality before somite formation, embryonic lethality before turning of embryo, embryonic lethality during organogenesis, increased ovary tumor incidence, intestine polyps, duodenum polyps, increased lung tumor incidence, abnormal anterior visceral endoderm morphology, abnormal granulosa cell morphology, pancreatic ductal adenocarcinoma, abnormal secondary ovarian follicle morphology, abnormal cumulus expansion, failure of cumulus expansion, increased keratinocyte proliferation, thick epidermis stratum basale, increased gastrointestinal tumor incidence, increased skin tumor incidence, increased stomach tumor incidence, decreased tumor latency, increased cholangiocarcinoma incidence, thick hair follicle outer rooth sheath" "chromatin binding, cytoplasm, DNA binding, nucleus, positive regulation of transcription from RNA polymerase II promoter, positive regulation of transcription, DNA-dependent, regulation of binding, regulation of transcription from RNA polymerase II promoter, sequence-specific DNA binding transcription factor activity, transcription activator activity, intracellular, regulation of transcription, regulation of transcription, DNA-dependent; transcription, branching involved in ureteric bud morphogenesis, negative regulation of cell proliferation, positive regulation of transcription from RNA polymerase II promoter, regulation of cell proliferation, transforming growth factor beta receptor signaling pathway, anterior/posterior pattern formation, cell proliferation, developmental growth, endoderm development, formation of anatomical boundary, gastrulation, gastrulation with mouth forming second, in utero embryonic development, kidney development, mesoderm development, metanephric mesenchyme morphogenesis, negative regulation of cell death, nephrogenic mesenchyme morphogenesis, neuron fate commitment, palate development, positive regulation of epithelial to mesenchymal transition, positive regulation of pathway-restricted SMAD protein phosphorylation, positive regulation of SMAD protein import into nucleus, regulation of cell proliferation, somite rostral/caudal axis specification, tissue morphogenesis, collagen binding, protein binding, transcription factor complex, activin responsive factor complex, BMP signaling pathway, centrosome, cytoplasm, cytosol, DNA binding, I-SMAD binding, identical protein binding, negative regulation of cell growth, negative regulation of protein catabolic process, negative regulation of transcription, DNA-dependent, nucleoplasm, nucleus, positive regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of transforming growth factor beta receptor signaling pathway, promoter binding, protein complex, protein homodimerization activity, R-SMAD binding, regulation of transforming growth factor beta receptor signaling pathway, regulation of transforming growth factor-beta2 production, response to hypoxia, SMAD binding, SMAD protein complex assembly, SMAD protein signal transduction, transcription factor complex, transforming growth factor beta receptor signaling pathway, transforming growth factor beta receptor, ommon-partner cytoplasmic mediator activity; " Wbcq7 Elac1 18 73894692 73914133 309 99.4% 0 0.0% 311 99.4% "endonuclease activity, endoribonuclease activity, producing 5'-phosphomonoesters, hydrolase activity, metal ion binding, nuclease activity, nucleus, tRNA 3'-trailer cleavage, tRNA processing" Wbcq7 Me2 18 73929694 73975046 741 86.8% 0 0.0% 854 86.8% "spleen hypoplasia, decreased thymocyte number, abnormal brain development, postnatal growth retardation, neonatal lethality, postnatal lethality, abnormal B cell differentiation, abnormal T cell differentiation, abnormal T cell physiology, increased double-negative T cell number, decreased double-positive T cell number, abnormal neuronal migration, decreased pro-B cell number, abnormal hair follicle orientation, kinked tail, cranioschisis, incomplete cephalic closure, absent eyelids, head bobbing, spinning, prenatal lethality, perinatal lethality, head shaking, spina bifida, abnormal cochlear sensory epithelium morphology, abnormal involuntary movement, abnormal neural tube closure, abnormal organ of Corti supporting cell morphology, cochlear outer hair cell degeneration, abnormal orientation of outer hair cell stereociliary bundles, craniorachischisis, whorled hair" "DNA binding, E-box binding, negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, protein-DNA complex assembly, regulation of transcription- DNA-dependent, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, sequence-specific DNA binding RNA polymerase recruiting transcription factor activity, TFIIB-class binding transcription factor activity, TFIIB-class transcription factor binding, transcription corepressor activity, transcription factor complex, transcription initiation factor activity, transcription initiation from RNA polymerase II promoter, multicellular organismal development, regulation of transcription, transcription, transcription regulator activity, bone mineralization, face morphogenesis, dontogenesis of dentine-containing tooth, Wnt receptor signaling pathway, canonical Wnt receptor signaling pathway, myoblast cell fate commitment, negative regulation of fat cell differentiation, protein binding, armadillo repeat domain binding, beta-catenin binding, cerebral cortex development, DNA binding, double-stranded DNA binding, negative regulation of canonical Wnt receptor signaling pathway, negative regulation of transcription, nucleus, orbitofrontal cortex development, positive regulation of transcription from RNA polymerase II promoter, positive regulation of transcription, DNA-dependent, promoter binding, protein C-terminus binding, regulation of smooth muscle cell proliferation, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, specific transcriptional repressor activity, membrane fraction, protein localization involved in establishment of planar polarity, cell adhesion, cell surface receptor linked signaling pathway, homophilic cell adhesion, integral to membrane, membrane, multicellular organismal development, neuropeptide signaling pathway, plasma membrane, receptor activity, signal transducer activity, neural tube closure, planar cell polarity pathway involved in neural tube closure, wound healing, anterior/posterior pattern formation, apical protein localization, establishment of body hair planar orientation, establishment of planar polarity, establishment of planar polarity of embryonic epithelium, hair follicle development, inner ear morphogenesis, lateral sprouting involved in lung morphogenesis, locomotory behavior, neural tube closure, neuron migration, orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis, planar dichotomous subdivision of terminal units involved in lung branching morphogenesis, regulation of actin cytoskeleton organization, Rho protein signal transduction, protein binding, cell-cell signaling, central nervous system development, G-protein coupled receptor activity, G-protein coupled receptor protein signaling pathway, gastrulation with mouth forming second, protein dimerization activity, regulation of neurotransmitter secretion, signal transduction, transmembrane receptor activity, calcium ion binding, integral to plasma membrane, cell adhesion, integral to membrane, membrane, mitochondrion, binding, catalytic activity, malate dehydrogenase (oxaloacetate-decarboxylating) activity, malate metabolic process, malic enzyme activity, metabolic process, metal ion binding, NAD or NADH binding, oxidation-reduction process, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, intracellular membrane-bounded organelle, mitochondrion" Wbcq7 Mro 18 74019039 74040987 381 83.2% 5 1.1% 458 84.3% "Nucleolus, nucleus, binding, biological_process" Wbcq7 Mapk4 18 74088140 74225013 713 98.8% 0 0.0% 722 98.8% "Kyphosis, abnormal lung development, atelectasis, pulmonary hypoplasia, impaired coordination, abnormal suckling behavior, unresponsive to tactile stimuli, abnormal vocalization, cyanosis, respiratory failure, respiratory distress, neonatal lethality, abnormal respiratory alveoli morphology, abnormal type II pneumocyte morphology, decreased heart weight, decreased liver weight, carpoptosis, decreased lung weight, decreased fetal weight, decreased birth weight" "Cytoplasm, ATP binding, cell cycle, kinase activity, MAP kinase activity, nucleotide binding, protein kinase activity, protein phosphorylation, protein serine/threonine kinase activity, signal transduction, transferase activity, protein binding, ATP binding, cell cycle, kinase activity, MAP kinase activity, nucleotide binding, protein kinase activity, protein phosphorylation, protein serine/threonine kinase activity, signal transduction, transferase activity" Ne_pctq1 Bod1 11 31565181 31571885 82 98.8% 0 0.0% 83 98.8% "cell cycle; cell division; chromosome, centromeric region; cytoplasm; cytoskeleton; kinetochore; mitosis; molecular_function" Ne_pctq1 D630024D03Rik 11 31690113 31724524 707 98.2% 13 1.8% 720 100.0% "biological_process; cellular_component; molecular_function" Ne_pctq1 Gm12107 11 31732660 31738214 78 97.5% 2 2.5% 80 100.0% "biological_process; cellular_component; molecular_function" Ne_pctq1 Cpeb4 11 31772226 31835634 115 89.8% 13 10.2% 128 100.0% "nucleic acid binding; nucleotide binding; RNA binding" Ne_pctq1 4930524B15Rik 11 31865592 31879651 73 97.3% 2 2.7% 75 100.0% "biological_process; cellular_component; molecular_function" Ne_pctq1 Nsg2 11 31900463 31959202 1103 95.9% 47 4.1% 1150 100.0% "cytoplasmic vesicle; dopamine receptor binding; dopamine receptor signaling pathway; endosome; Golgi apparatus; integral to membrane; membrane" Ne_pctq1 Gm12108 11 31995261 32001228 129 98.5% 2 1.5% 131 100.0% "biological_process; cellular_component; molecular_function" Ne_pctq1 Il9r 11 32087541 32100279 152 43.3% 34 9.7% 351 53.0% "increased susceptibility to experimental autoimmune encephalomyelitis, abnormal regulatory T cell physiology, increased T-helper 1 cell number" "cytokine receptor activity; cytokine-mediated signaling pathway; extracellular region; integral to membrane; membrane; plasma membrane; receptor activity; signal transduction; cytokine-mediated signaling pathway; interleukin-9 binding; interleukin-9 receptor activity; positive regulation of cell growth" Ne_pctq1 Snrnp25 11 32105415 32108984 43 55.1% 1 1.3% 78 56.4% "mRNA processing; RNA splicing; spliceosomal complex; U12-type spliceosomal complex; nucleus; molecular_function" Ne_pctq1 Rhbdf1 11 32109585 32122300 56 35.4% 2 1.3% 158 36.7% "endoplasmic reticulum; Golgi apparatus; integral to membrane; membrane; metabolic process; receptor activity; serine-type endopeptidase activity; signal transduction" Ne_pctq1 Nprl3 11 32125628 32167707 227 39.6% 30 5.2% 573 44.9% "abnormal erythropoiesis, abnormal liver development, anemia, abnormal hemoglobin, abnormal red blood cell, decreased mean corpuscular volume, anisocytosis, poikilocytosis, decreased hemoglobin content, pallor, decreased mean corpuscular hemoglobin, lethality throughout fetal growth and development" "biological_process; cellular_component; molecular_function" Ne_pctq1 Mpg 11 32126505 32132700 29 46.0% 1 1.6% 63 47.6% "autoimmune response, abnormal pancreatic beta cell physiology, decreased incidence of chemically-induced tumors, decreased susceptibility to autoimmune diabetes, abnormal fat pad morphology, increased circulating glucose level, increased apoptosis, enhanced lipolysis, increased CD4-positive T cell number, abnormal physiological response to xenobiotic, increased physiological sensitivity to xenobiotic, small pancreatic islets, pancreatic islet cell apoptosis" "alkylbase DNA N-glycosylase activity; catalytic activity; DNA binding; DNA repair; hydrolase activity; nucleus; response to DNA damage stimulus; alkylbase DNA N-glycosylase activity; base-excision repair; depurination; DNA N-glycosylase activity; identical protein binding; nucleoplasm" Ne_pctq1 Hba-x 11 32176400 32178116 18 48.6% 2 5.4% 37 54.1% "abnormal mean corpuscular volume, anemia, abnormal hemoglobin, abnormal mean corpuscular hemoglobin, postnatal growth retardation, decreased litter size, prenatal lethality, abnormal red blood cell, abnormal erythrocyte morphology, anisocytosis, poikilocytosis, polychromatophilia, increased platelet cell number" "heme binding; hemoglobin complex; iron ion binding; metal ion binding; oxygen binding; oxygen transport; oxygen transporter activity; transport; erythrocyte maturation; negative regulation of transcription from RNA polymerase II promoter" Ne_pctq1 Hba-a1 11 32183511 32184465 0 #DIV/0! 0 #DIV/0! 0 #DIV/0! "abnormal mean corpuscular volume, anemia, hemolytic anemia, abnormal hemoglobin, abnormal mean corpuscular hemoglobin, perinatal lethality, abnormal red blood cell, hyperoxia, abnormal erythrocyte morphology, decreased mean corpuscular volume, reticulocytosis, anisocytosis, poikilocytosis, decreased hemoglobin content, increased aerobic running capacity, pallor, decreased fetal size, polychromatophilia, increased oxygen consumption, increased platelet cell number, decreased mean corpuscular hemoglobin, abnormal mitochondrial physiology, increased carbon dioxide production, abnormal skeletal muscle fiber type ratio, leptocytosis" "erythrocyte development; in utero embryonic development" Ne_pctq1 Hbq1b 11 32186965 32187784 3 37.5% 1 12.5% 8 50.0% "metal ion binding; oxygen transport; oxygen transporter activity; transport; cellular_component" Ne_pctq1 Hba-a2 11 32196489 32197298 1 100.0% 0 0.0% 1 100.0% "erythrocyte development ; in utero embryonic development; beta-amyloid binding; cytosolic small ribosomal subunit; heme binding; hemoglobin complex; hydrogen peroxide catabolic process; negative regulation of blood pressure; organic acid binding; oxygen binding; positive regulation of cell death; protein heterooligomerization; regulation of sensory perception of pain; soluble fraction; erythrocyte development; in utero embryonic development; beta-amyloid binding; cytosolic small ribosomal subunit; heme binding; hemoglobin complex; hydrogen peroxide catabolic process; negative regulation of blood pressure; organic acid binding; oxygen binding; positive regulation of cell death; protein heterooligomerization; regulation of sensory perception of pain; soluble fraction""; metal ion binding" Ne_pctq1 Hbq1a 11 32200069 32200873 27 93.1% 0 0.0% 29 93.1% "metal ion binding; oxygen transport; oxygen transporter activity; transport; cellular_component" Ne_pctq1 Sh3pxd2b 11 32247820 32328173 1270 79.8% 48 3.0% 1591 82.8% "abnormal middle ear morphology, decreased bone mineral density, abnormal neurocranium morphology, short mandible, short maxilla, abnormal xiphoid process, kyphosis, lordosis, abnormal heart shape, abnormal mitral valve morphology, abnormal craniofacial morphology, domed cranium, short snout, decreased body weight, decreased body size, ocular hypertelorism, abnormal cornea morphology, corneal opacity, abnormal postnatal growth, postnatal growth retardation, decreased white adipose tissue amount, increased susceptibility to otitis media, infertility, male infertility, female infertility, postnatal lethality, abnormal tooth morphology, abnormal skeleton development, abnormal myocardial trabeculae morphology, micrognathia, exophthalmos, abnormal cranial suture morphology, abnormal sagittal suture morphology, synechia, short nasal bone, decreased brainstem auditory evoked potential, abnormal eye anterior chamber, ocular hypertension, abnormal heart ventricle morphology, decreased heart rate, abnormal ilium morphology, mitral valve prolapse, phthisis bulbi, decreased cranium height, decreased subcutaneous adipose tissue amount, decreased abdominal adipose tissue amount, proportional dwarf, enlarged eye anterior chamber, abnormal basicranium morphology, thin interventricular septum" "cytoplasm; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; SH2 domain binding; cell communication; cell differentiation; cell junction; cell projection; phosphatidylinositol binding; phosphatidylinositol-3-phosphate binding; positive regulation of fat cell differentiation" Ne_pctq1 Ubtd2 11 32355370 32416687 482 97.8% 8 1.6% 493 99.4% "cytoplasm; biological_process; molecular_function" Ne_pctq1 Efcab9 11 32422751 32432081 56 100.0% 0 0.0% 56 100.0% "calcium ion binding; biological_process; cellular_component" Ne_pctq1 Stk10 11 32433305 32524587 1034 75.1% 47 3.4% 1377 78.5% abnormal T cell physiology "ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein phosphorylation; transferase activity; protein serine/threonine kinase activity" Ne_pctq1 Fbxw11 11 32542724 32646789 703 72.6% 7 0.7% 968 73.3% "cytoplasm; cytosol; nucleus; protein dephosphorylation; protein polyubiquitination; SCF ubiquitin ligase complex; ubiquitin-protein ligase activity; cell cycle; rhythmic process; Wnt receptor signaling pathway; negative regulation of NF-kappaB import into nucleus; positive regulation of circadian rhythm; positive regulation of gene-specific transcription; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transcription activator activity; protein binding; negative regulation of gene-specific transcription; positive regulation of proteolysis; proteasomal ubiquitin-dependent protein catabolic process; protein destabilization; protein polyubiquitination; protein ubiquitination; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; specific transcriptional repressor activity; ubiquitin-protein ligase activity" Ne_pctq1 Gm10462 11 32625838 32626208 0 #DIV/0! 0 #DIV/0! 0 #DIV/0! "biological_process; cellular_component; molecular_function" Ne_pctq1 4930555O08Rik 11 32689762 32690725 3 37.5% 0 0.0% 8 37.5% "biological_process; cellular_component; molecular_function" Ne_pctq1 1700008A04Rik 11 32718529 32724605 108 85.7% 0 0.0% 126 85.7% "integral to membrane; membrane; biological_process; molecular_function" Ne_pctq1 Gm12111 11 32803137 32826160 257 84.5% 2 0.7% 304 85.2% "biological_process; cellular_component; molecular_function" Ne_pctq1 Gm12114 11 32968551 32980521 125 83.3% 4 2.7% 150 86.0% "biological_process; cellular_component; molecular_function" Ne_pctq1 Fgf18 11 33017430 33047400 66 88.0% 4 5.3% 75 93.3% "delayed bone ossification, abnormal neurocranium morphology, abnormal rib morphology, kyphosis, maxilla hypoplasia, decreased body weight, cyanosis, neonatal lethality, perinatal lethality, postnatal lethality, abnormal limb morphology, abnormal tail morphology, abnormal skeleton development, abnormal axial skeleton morphology, abnormal skeleton extremities morphology, abnormal craniofacial bone morphology, abnormal fibula morphology, abnormal respiratory mechanics, short tibia, abnormal cranial suture morphology, abnormal metatarsal bone morphology, increased width of hypertrophic chondrocyte zone, delayed endochondral bone ossification, delayed intramembranous bone ossification, abnormal long bone epiphyseal plate proliferative zone, abnormal spine curvature, short radius, bowed tibia, short ulna, bowed radius, small thoracic cavity, abnormal skeleton morphology, increased long bone epiphyseal plate size, abnormal osteoblast differentiation, decreased birth body size, failure of palatal shelf elevation, cleft secondary palate" "positive regulation of ERK1 and ERK2 cascade; growth factor activity; fibroblast growth factor receptor signaling pathway; positive regulation of chondrocyte differentiation; angiogenesis; chondrocyte development; endochondral ossification; intramembranous ossification; lung development; ossification; positive regulation of cell proliferation; positive regulation of vascular endothelial growth factor receptor signaling pathway; extracellular region; fibroblast growth factor receptor signaling pathway; nervous system development; nucleolus; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding; fibroblast growth factor receptor binding; signal transduction" Ne_pctq1 Npm1 11 33052287 33063206 51 100.0% 0 0.0% 51 100.0% "abnormal thrombopoiesis, increased bone marrow cell number, abnormal cell proliferation, increased cell proliferation, decreased cell proliferation, abnormal liver morphology, abnormal eye development, anophthalmia, anemia, abnormal apoptosis, decreased embryo size, abnormal placenta development, abnormal yolk sac morphology, embryonic growth arrest, B cell derived lymphoma, neonatal lethality, abnormal brain morphology, abnormal proerythroblast morphology, abnormal megakaryocyte morphology, abnormal reticulocyte morphology, increased mean corpuscular volume, anisocytosis, abnormal cell cycle, abnormal vitelline vasculature morphology, abnormal forebrain development, abnormal embryonic hematopoiesis, altered tumor morphology, pallor, chromosome breakage, small placenta, increased apoptosis, embryonic lethality during organogenesis, lethality throughout fetal growth and development" "cell growth; cell volume homeostasis; centrosome; cytoplasm; cytosol; granular component; large ribosomal subunit; negative regulation of nuclear mRNA splicing, via spliceosome; nuclear speck; nucleocytoplasmic transport; nucleolus; nucleoplasm; nucleus; positive regulation of cell proliferation; positive regulation of cellular biosynthetic process; positive regulation of protein kinase activity; ribosomal large subunit biogenesis; ribosomal small subunit biogenesis; ribosomal small subunit export from nucleus; RNA binding; rRNA binding; rRNA export from nucleus; small ribosomal subunit; nucleic acid binding; positive regulation of centrosome duplication; regulation of DNA damage response, signal transduction by p53 class mediator; cell volume homeostasis; positive regulation of cell proliferation; positive regulation of cellular biosynthetic process; protein destabilization; protein localization; regulation of cell cycle; regulation of centrosome duplication; ribosomal large subunit biogenesis; ribosomal large subunit export from nucleus; ribosomal small subunit biogenesis; rRNA export from nucleus; protein binding; cell aging; centrosome; centrosome cycle; cytoplasm; DNA binding; DNA repair; enzyme binding; histone binding; negative regulation of cell proliferation; negative regulation of centrosome duplication; NF-kappaB binding; nucleocytoplasmic transport; nucleolus; nucleoplasm; nucleosome assembly; nucleus; phosphatidylinositol-3,4,5-trisphosphate binding; positive regulation of catalytic activity; positive regulation of DNA metabolic process; positive regulation of DNA replication; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription; protein heterodimerization activity; protein homodimerization activity; protein homooligomerization; protein localization; protein oligomerization; regulation of anti-apoptosis; regulation of endodeoxyribonuclease activity; regulation of endoribonuclease activity; response to stress; ribonucleoprotein complex; ribosomal large subunit binding; ribosomal small subunit binding; RNA binding; spindle pole centrosome; Tat protein binding; transcription coactivator activity; unfolded protein binding" Ne_pctq1 Tlx3 11 33100754 33103541 13 92.9% 1 7.1% 14 100.0% "abnormal spinal cord morphology, abnormal sensory neuron morphology, abnormal sensory neuron projections, cyanosis, abnormal breathing pattern, respiratory failure, respiratory distress, apnea, neonatal lethality, premature death, abnormal GABAergic neuron morphology, abnormal glutaminergic neuron, abnormal nervous system physiology, abnormal spinal cord interneuron morphology, tachypnea, abnormal spinal cord dorsal horn morphology, medulloblastoma, absent gastric milk in neonates" "nucleus; DNA binding; multicellular organismal development; regulation of transcription; regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription regulator activity; cell fate specification; negative regulation of neuron differentiation; neuron fate specification; cell fate specification; central nervous system development; neuron differentiation; neuron migration; regulation of respiratory gaseous exchange by neurological system process; respiratory gaseous exchange; protein binding" Ne_pctq1 Gm12116 11 33104055 33121477 190 96.0% 6 3.0% 198 99.0% "biological_process; cellular_component; molecular_function" Ne_pctq1 Ranbp17 11 33111795 33413746 3195 94.9% 31 0.9% 3366 95.8% "binding; cytoplasm; intracellular protein transport; mRNA transport; nuclear pore; nucleus; protein transport; protein transporter activity; transmembrane transport; transport; nucleocytoplasmic transport; Ran GTPase binding" Ne_pctq1 Gabrp 11 33450781 33478959 415 85.7% 1 0.2% 484 86.0% "cell junction; chloride channel activity; chloride channel complex; chloride transport; extracellular ligand-gated ion channel activity; integral to membrane; ion channel activity; ion transmembrane transport; ion transport; membrane; plasma membrane; postsynaptic membrane; receptor activity; signal transduction; synapse; transport; GABA-A receptor activity" Ne_pctq1 D130052B06Rik 11 33499302 33524013 679 98.5% 5 0.7% 689 99.3% "biological_process; cellular_component; molecular_function" Ne_pctq1 Kcnip1 11 33529339 33893152 6158 97.4% 86 1.4% 6324 98.7% "ion channel activity; ion transmembrane transport; ion transport; membrane; potassium channel activity; potassium ion transmembrane transport; potassium ion transport; regulation of ion transmembrane transport; transport; voltage-gated ion channel activity; calcium ion binding; dendrite; neuronal cell body; plasma membrane; positive regulation of action potential; potassium channel regulator activity; protein heterodimerization activity; protein N-terminus binding" Ne_pctq1 Gm12119 11 33595894 33597908 53 96.4% 2 3.6% 55 100.0% "biological_process; cellular_component; molecular_function" Ne_pctq1 Gm12120 11 33605550 33611435 133 91.7% 11 7.6% 145 99.3% "biological_process; cellular_component; molecular_function" Ne_pctq1 Kcnmb1 11 33863013 33873641 241 99.6% 1 0.4% 242 100.0% "abnormal vasoconstriction, increased heart weight, increased systemic arterial blood pressure, abnormal renal glomerular filtration rate, increased vasoconstriction, abnormal vascular smooth muscle physiology, abnormal muscle contractility" "integral to membrane; ion channel activity; ion transmembrane transport; ion transport; membrane; potassium ion transport; transport; calcium-activated potassium channel activity; potassium ion transmembrane transport; voltage-gated potassium channel complex; potassium channel regulator activity; response to calcium ion" Ne_pctq1 4930469K13Rik 11 33873961 33998554 2318 99.3% 4 0.2% 2335 99.4% "biological_process; cellular_component; molecular_function" Ne_pctq1 Lcp2 11 33946920 33992295 720 99.6% 1 0.1% 723 99.7% "enlarged spleen, abnormal Peyer's patch morphology, small thymus, decreased thymocyte number, thymus hypoplasia, arrested T cell differentiation, abnormal T cell activation, autoimmune response, liver inflammation, lung inflammation, abnormal lymphatic vessel morphology, perinatal lethality, abnormal T cell differentiation, abnormal double-negative T cell morphology, abnormal double-positive T cell morphology, abnormal effector T cell morphology, abnormal T cell physiology, increased IgG level, increased IgE level, abnormal cytokine secretion, intestinal edema, abnormal thymocyte activation, abnormal T cell subpopulation ratio, abnormal negative T cell selection, abnormal positive T cell selection, decreased T cell number, impaired NK cell cytolysis, decreased double-negative T cell number, increased double-negative T cell number, increased double-positive T cell number, decreased double-positive T cell number, decreased T cell proliferation, abnormal platelet activation, decreased T cell apoptosis, decreased NK T cell number, increased NK cell number, increased CD4-positive T cell number, decreased CD4-positive T cell number, increased CD8-positive T cell number, decreased CD8-positive T cell number, decreased single-positive T cell number, lymph node hypoplasia, increased gamma-delta T cell number, decreased interferon-gamma secretion, decreased interleukin-2 secretion, decreased platelet aggregation" "cytoplasm; cytokine secretion; mast cell activation; cytosol" Ne_pctq1 Gm12121 11 34041827 34043421 33 94.3% 1 2.9% 35 97.1% "biological_process; cellular_component; molecular_function" Ne_pctq1 Foxi1 11 34104338 34108089 41 89.1% 2 4.3% 46 93.5% "abnormal inner ear morphology, abnormal cochlea morphology, abnormal membranous labyrinth, renal tubular acidosis, abnormal cerebellum morphology, circling, hyperactivity, impaired swimming, male infertility, deafness, perinatal lethality, abnormal epididymis morphology, absent otoliths, absent cochlea, absent modiolus, abnormal nephron morphology, absent vestibule, enlarged saccule, enlarged utricle, absent endocochlear potential, abnormal sperm physiology, abnormal kidney collecting duct, abnormal common crus morphology, increased epididymis weight, enlarged epididymis, head tilt, abnormal temporal bone morphology, dilated endolymphatic duct, dilated endolymphatic sac, dilated lateral semicircular canal, dilated posterior semicircular canal, increased apoptosis, inner ear cysts, impaired hearing, absent pinna reflex, kinked sperm flagellum, increased urine pH" "nucleus; positive regulation of gene-specific transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; promoter binding; sequence-specific DNA binding; transcription activator activity; DNA binding; regulation of transcription; regulation of transcription, DNA-dependent; transcription; inner ear morphogenesis; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; DNA bending activity; double-stranded DNA binding; epidermal cell fate specification; negative regulation of gene-specific transcription from RNA polymerase II promoter; otic placode formation; pattern specification process; regulation of transcription factor activity; sequence-specific enhancer binding RNA polymerase II transcription factor activity; specific RNA polymerase II transcription factor activity; specific transcriptional repressor activity; transcription factor binding; transcription factor complex" Ne_pctq1 Dock2 11 34126815 34597394 6689 91.5% 267 3.7% 7312 95.1% "abnormal immune system morphology, abnormal spleen morphology, spleen hypoplasia, abnormal Peyer's patch morphology, abnormal spleen white pulp morphology, abnormal hematopoietic system morphology/development, abnormal CD4-positive T cell morphology, abnormal T cell physiology, abnormal cell migration, abnormal leukocyte migration, decreased lymphocyte cell number, decreased T cell number, decreased double-positive T cell number, lymph node hypoplasia, decreased marginal zone B cell number, decreased mature B cell number, impaired neutrophil chemotaxis, increased sensitivity to xenobiotic induced morbidity/mortality" "positive regulation of Rac protein signal transduction; cytoskeleton organization; cytoplasm; cytoskeleton; GTP binding; GTPase binding; guanyl-nucleotide exchange factor activity; membrane; regulation of catalytic activity; alpha-beta T cell activation; alpha-beta T cell proliferation; chemotaxis; establishment of T cell polarity; immunological synapse formation; membrane raft polarization; negative thymic T cell selection; positive thymic T cell selection; Rac GTPase activator activity; T cell activation; T cell proliferation; cytosol; Rac guanyl-nucleotide exchange factor activity; regulation of catalytic activity; T cell receptor binding" Ne_pctq1 4930403D09Rik 11 34199707 34208113 121 91.0% 11 8.3% 133 99.2% "biological_process; cellular_component; molecular_function" Ne_pctq1 Fam196b 11 34214822 34322639 1419 83.5% 116 6.8% 1699 90.3% "biological_process; cellular_component; molecular_function" Ne_pctq1 Ccdc99 11 34622692 34647143 413 99.3% 1 0.2% 416 99.5% "cell cycle; cell division; chromosome, centromeric region; cytoplasm; cytoskeleton; kinetochore; mitosis; condensed chromosome outer kinetochore; establishment of mitotic spindle orientation; kinetochore binding; mitotic metaphase plate congression; nucleus; protein localization to kinetochore; spindle pole" Ne_pctq1 Gm12711 11 34693841 34696033 24 100.0% 0 0.0% 24 100.0% "biological_process; cellular_component; molecular_function" Ne_pctq1 Slit3 11 34934726 35522009 3730 81.0% 24 0.5% 4604 81.5% "heart right ventricle hypertrophy, absent kidney, abnormal liver morphology, thin diaphragm muscle, abnormal spinal cord morphology, atelectasis, lung hemorrhage, decreased body weight, respiratory distress, premature death, abnormal kidney morphology, abnormal diaphragm morphology, abnormal axon guidance, intestinal obstruction, renal hypoplasia, herniated diaphragm, herniated intestine, abnormal spinal cord lateral column morphology, abnormal spinal cord morphology, perinatal lethality, abnormal axon guidance, abnormal embryonic/fetal subventricular zone morphology, abnormal neurite morphology, abnormal spinal cord lateral column morphology" "axon guidance; extracellular space; calcium ion binding; cell differentiation; extracellular region; multicellular organismal development; nervous system development; negative regulation of cell proliferation; negative regulation of gene expression; organ morphogenesis; organ morphogenesis; axon extension involved in axon guidance; axon guidance; extracellular space; membrane fraction; mitochondrion; negative chemotaxis; negative regulation of cell growth; negative regulation of chemokine-mediated signaling pathway; Roundabout binding; Roundabout signaling pathway; receptor binding" Moq1 Sp100 1 87546563 87606573 381 98.4% 0 0.0% 387 98.4% "binding; DNA binding; protein binding; chromo shadow domain binding; cytoplasm; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; general transcriptional repressor activity; identical protein binding; kinase binding; negative regulation of cellular component movement; negative regulation of DNA binding; negative regulation of transcription; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of viral transcription; nuclear periphery; nucleolus; nucleus; PML body; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; protein domain specific binding; protein homodimerization activity; response to cytokine stimulus; response to interferon-gamma; response to retinoic acid; response to type I interferon; transcription coactivator activity; transcription corepressor activity; transcription factor binding" Moq1 n-R5s215 1 87571457 87571560 1 100.0% 0 0.0% 1 100.0% Moq1 A630001G21Rik 1 87613658 87675218 440 31.2% 0 0.0% 1411 31.2% "biological_process; cellular_component; molecular_function" Moq1 Cab39 1 87690016 87748151 308 78.4% 0 0.0% 393 78.4% "binding; cytoplasm; kinase binding; protein complex; protein heterooligomerization; protein serine/threonine kinase activity; regulation of fatty acid oxidation; calcium ion binding" Moq1 Itm2c 1 87790856 87805250 142 94.7% 0 0.0% 150 94.7% "ATP binding; lysosome; integral to membrane; membrane; induction of programmed cell death; beta-amyloid binding; Golgi apparatus; lysosome; negative regulation of neuron projection development; neuron differentiation; perinuclear region of cytoplasm; membrane fraction" Moq1 4933407L21Rik 1 87825058 87837199 132 78.6% 0 0.0% 168 78.6% "biological_process; cellular_component; molecular_function" Moq1 Gpr55 1 87836112 87857630 275 79.3% 0 0.0% 347 79.3% "abnormal cancellous bone morphology; abnormal osteoclast physiology; no abnormal phenotype detected; abnormal osteoclast morphology; increased osteoclast cell number; decreased osteoclast cell number; increased bone mass; abnormal osteoclast differentiation; abnormal physiological response to xenobiotic" "G-protein coupled receptor activity; G-protein coupled receptor protein signaling pathway; integral to membrane; membrane; receptor activity; signal transducer activity; signal transduction; activation of phospholipase C activity; bone resorption; cannabinoid receptor activity; G-protein coupled receptor protein signaling pathway; integral to plasma membrane; negative regulation of osteoclast differentiation; plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of Rho protein signal transduction" Moq1 Spata3 1 87913391 87926533 75 83.3% 0 0.0% 90 83.3% "biological_process; cellular_component; molecular_function" Moq1 2810459M11Rik 1 87942843 87952031 94 91.3% 0 0.0% 103 91.3% "extracellular region; protein binding; biological_process" Moq1 Psmd1 1 87960962 88059363 1011 91.5% 0 0.0% 1105 91.5% "binding; enzyme regulator activity; proteasome complex; regulation of catalytic activity; regulation of protein catabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle" Moq1 Htr2b 1 87995601 88008545 130 92.9% 0 0.0% 140 92.9% "abnormal heart development; absent trabeculae carneae; decreased body weight; abnormal cardiovascular system physiology; decreased embryo size; reduced fertility; postnatal lethality; abnormal cardiovascular system morphology; no abnormal phenotype detected; disorganized myocardium; decreased heart weight; dilated heart atrium; abnormal fetal cardiomyocyte proliferation; embryonic growth retardation; abnormal heart ventricle morphology; embryonic lethality during organogenesis; decreased right ventricle systolic pressure" "cellular response to temperature stimulus; cytoplasm; drug binding; G-protein coupled receptor internalization; plasma membrane; response to drug; serotonin binding; serotonin receptor activity; G-protein coupled receptor activity; integral to membrane; membrane; receptor activity; signal transducer activity; signal transduction; activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; cardiac muscle hypertrophy; embryonic morphogenesis; ERK1 and ERK2 cascade; heart development; heart morphogenesis; negative regulation of apoptosis; neural crest cell differentiation; neural crest cell migration; positive regulation of cell division; positive regulation of cytokine secretion; positive regulation of endothelial cell proliferation; Ras GTPase activator activity; regulation of behavior; calcium channel activity; calcium ion transmembrane transport; calcium-mediated signaling; cellular response to calcium ion; cGMP biosynthetic process; cytoplasm; drug binding; ERK1 and ERK2 cascade; G-protein alpha-subunit binding; G-protein coupled receptor internalization; G-protein coupled receptor protein signaling pathway; intestine smooth muscle contraction; negative regulation of autophagy; negative regulation of cell death; phosphatidylinositol 3-kinase cascade; phosphatidylinositol phospholipase C activity; phosphorylation; plasma membrane; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of endothelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of nitric-oxide synthase activity; protein kinase C signaling cascade; regulation of behavior; release of sequestered calcium ion into cytosol; response to drug; serotonin binding; serotonin receptor activity; serotonin receptor signaling pathway; vasoconstriction; activation of phospholipase C activity by serotonin receptor signaling pathway; serotonin receptor activity" Moq1 Armc9 1 88051355 88174859 119 85.0% 0 0.0% 140 85.0% "binding; biological_process; cellular_component" Moq1 Gm16341 1 88172084 88197950 147 56.3% 0 0.0% 261 56.3% "biological_process; cellular_component; molecular_function" Moq1 B3gnt7 1 88200043 88203878 7 43.8% 0 0.0% 16 43.8% "galactosyltransferase activity; Golgi apparatus; integral to membrane; membrane; transferase activity; transferase activity, transferring glycosyl groups; acetylglucosaminyltransferase activity; protein glycosylation" Moq1 Gm5258 1 88219842 88222008 17 38.6% 0 0.0% 44 38.6% "biological_process; cellular_component; molecular_function" Moq1 Ncl 1 88247071 88255939 26 76.5% 0 0.0% 34 76.5% "abnormal vision; abnormal brain morphology; loss of GABAergic neurons" "nucleolus; nucleoplasm; nucleus; RNA binding; cytoplasm; DNA binding; nucleic acid binding; nucleotide binding; protein binding; angiogenesis; cell cortex; nucleolus; nucleus; protein C-terminus binding; ribonucleoprotein complex; RNA binding; telomeric DNA binding; lysosome; vacuolar lumen; cell death; lysosome organization; visual perception; endoplasmic reticulum; Golgi apparatus; integral to membrane; lysosomal lumen acidification; lysosomal membrane; lysosome; perinuclear region of cytoplasm" Moq1 Snora75 1 88247744 88247876 0 #DIV/0! 0 #DIV/0! 0 - "biological_process; cellular_component; molecular_function" Moq1 Snord82 1 88252835 88252902 0 #DIV/0! 0 #DIV/0! 0 - Moq1 C130036L24Rik 1 88256149 88270366 129 63.5% 0 0.0% 203 63.5% "biological_process; cellular_component; molecular_function" Moq1 Nmur1 1 88282817 88284737 18 100.0% 0 0.0% 18 100.0% "increased thermal nociceptive threshold; no abnormal phenotype detected; abnormal response/metabolism to endogenous compounds" "integral to plasma membrane; neuropeptide signaling pathway; G-protein coupled receptor activity; G-protein coupled receptor protein signaling pathway; membrane; receptor activity; signal transducer activity; signal transduction; neuropeptide receptor activity; activation of phospholipase C activity; activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; calcium ion transport; calcium-mediated signaling; chloride transport; inositol phosphate-mediated signaling; integral to membrane; membrane fraction; neuromedin U receptor activity; neuropeptide signaling pathway; plasma membrane; synaptic transmission" Moq1 1700019O17Rik 1 88322917 88324624 22 100.0% 0 0.0% 22 100.0% "biological_process; cellular_component; molecular_function" Moq1 Ptma 1 88423311 88427273 18 75.0% 0 0.0% 24 75.0% "nucleus; anti-apoptosis; negative regulation of caspase activity" Moq1 Pde6d 1 88439569 88479204 345 93.8% 0 0.0% 368 93.8% "GTPase inhibitor activity; regulation of catalytic activity; regulation of GTP catabolic process; 3',5'-cyclic-nucleotide phosphodiesterase activity; metabolic process; response to stimulus; visual perception; protein binding; 3',5'-cyclic-GMP phosphodiesterase activity; phototransduction" Moq1 Cops7b 1 88479479 88503553 309 93.1% 0 0.0% 332 93.1% "cytoplasm; nucleus; signalosome; biological_process; molecular_function" Moq1 Nppc 1 88562866 88567147 19 95.0% 0 0.0% 20 95.0% "abnormal cartilage morphology; short limbs; short tail; abnormal sensory neuron projections; small testis; decreased body height; decreased body length; decreased body weight; decreased body size; postnatal growth retardation; postnatal lethality; disproportionate dwarf; short tibia; short fibula; abnormal long bone epiphyseal plate morphology; decreased width of hypertrophic chondrocyte zone; abnormal long bone epiphyseal plate proliferative zone; decreased length of long bones; abnormal miniature excitatory postsynaptic currents; abnormal neuron physiology; abnormal female meiosis; abnormal vertebral epiphyseal plate morphology; decreased long bone epiphyseal plate size; disorganized long bone epiphyseal plate; decreased cranium height; decreased physiological sensitivity to xenobiotic" "cGMP biosynthetic process; receptor binding; ossification; regulation of blood vessel size; cGMP biosynthetic process; growth plate cartilage chondrocyte differentiation; growth plate cartilage chondrocyte proliferation; organ development; post-embryonic development; regulation of multicellular organism growth; cGMP biosynthetic process; extracellular space; hormone activity; negative regulation of cell proliferation; negative regulation of DNA metabolic process; peptide hormone receptor binding; positive regulation of cGMP biosynthetic process; positive regulation of osteoblast differentiation; positive regulation of vasodilation; protein homodimerization activity; receptor binding; receptor guanylyl cyclase signaling pathway; extracellular region; neuropeptide hormone activity" Moq1 Dis3l2 1 88600418 88946665 1717 97.4% 0 0.0% 1763 97.4% "exonuclease activity; hydrolase activity; metabolic process; nuclease activity; ribonuclease activity; RNA binding; cellular_component" Moq1 Alppl2 1 88983265 88986503 36 100.0% 0 0.0% 36 100.0% "decreased litter size; no abnormal phenotype detected; long gestation period; embryonic growth retardation; embryonic lethality before implantation" "alkaline phosphatase activity; anchored to membrane; catalytic activity; dephosphorylation; hydrolase activity; integral to membrane; membrane; metabolic process; metal ion binding; phosphatase activity; plasma membrane" Moq1 Alpi 1 88994579 88998181 8 57.1% 0 0.0% 14 57.1% "hydrolase activity; metabolic process; alkaline phosphatase activity; dephosphorylation; external side of plasma membrane; magnesium ion binding; phosphorus metabolic process; zinc ion binding" Moq1 Akp3 1 89021583 89024487 34 89.5% 0 0.0% 38 89.5% "increased body weight; abnormal lipid level; increased circulating triglyceride level; abnormal lipid absorption" "anchored to membrane; catalytic activity; dephosphorylation; hydrolase activity; membrane; metabolic process; metal ion binding; phosphatase activity; plasma membrane; multicellular organism growth; neural tube development; neurogenesis; tail morphogenesis; alkaline phosphatase activity; dephosphorylation; external side of plasma membrane; magnesium ion binding; phosphorus metabolic process; zinc ion binding" Moq1 Ecel1 1 89044230 89053096 62 82.7% 0 0.0% 75 82.7% "thin diaphragm muscle; abnormal muscle innervation; abnormal neuromuscular synapse morphology; abnormal phrenic nerve morphology; atelectasis; cyanosis; respiratory failure; neonatal lethality; anoxia" "metalloendopeptidase activity; hydrolase activity; integral to membrane; membrane; metal ion binding; metallopeptidase activity; peptidase activity; proteolysis; intracellular signal transduction; neuropeptide signaling pathway; integral to plasma membrane" Moq1 1700027L20Rik 1 89083240 89084978 23 79.3% 0 0.0% 29 79.3% "biological_process; cellular_component; molecular_function" Moq1 Chrnd 1 89087227 89096644 76 91.6% 0 0.0% 83 91.6% "nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; cell junction; extracellular ligand-gated ion channel activity; integral to membrane; ion channel activity; ion transmembrane transport; ion transport; membrane; postsynaptic membrane; receptor activity; signal transduction; synapse; transport; acetylcholine binding; nicotinic acetylcholine-activated cation-selective channel activity; regulation of membrane potential; nicotinic acetylcholine-gated receptor-channel complex; protein binding; cation transport; ion transmembrane transport; ligand-gated ion channel activity; musculoskeletal movement; nicotinic acetylcholine-activated cation-selective channel activity; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; skeletal muscle tissue growth" Moq1 Chrng 1 89102386 89108410 51 70.8% 0 0.0% 72 70.8% "hindlimb paralysis; abnormal motor neuron morphology; abnormal muscle innervation; abnormal neuromuscular synapse morphology; abnormal phrenic nerve morphology; dehydration; abnormal suckling behavior; cyanosis; abnormal breathing pattern; perinatal lethality; postnatal lethality; abnormal muscle physiology; abnormal diaphragm morphology; abnormal neuron morphology; abnormal endplate potential; abnormal skeletal muscle fiber morphology; abnormal miniature endplate potential; increased motor neuron number; abnormal dendrite morphology; abnormal neurite morphology; increased variability of skeletal muscle fiber size" "nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; postsynaptic membrane; cell junction; extracellular ligand-gated ion channel activity; integral to membrane; ion channel activity; ion transmembrane transport; ion transport; membrane; receptor activity; signal transduction; synapse; transport; nicotinic acetylcholine-activated cation-selective channel activity; regulation of membrane potential; protein binding; cation transport; ion transmembrane transport; ligand-gated ion channel activity; nicotinic acetylcholine-activated cation-selective channel activity; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane" Moq1 Eif4e2 1 89110489 89137063 179 76.8% 0 0.0% 233 76.8% "cytoplasm; regulation of translation; RNA binding; translation; translation initiation factor activity; translational initiation; protein binding; mRNA cap binding complex" Moq1 Efhd1 1 89160938 89207414 601 84.6% 0 0.0% 710 84.6% "mitochondrial inner membrane; mitochondrion; calcium ion binding; neuron projection development" Moq1 Gigyf2 1 89223628 89345721 772 95.2% 0 0.0% 811 95.2% "motor neuron degeneration; decreased body length; decreased body weight; impaired coordination; neonatal lethality; abnormal motor capabilities/coordination/movement; postnatal lethality; neurodegeneration; abnormal cell cycle; abnormal food intake; alpha-synuclein inclusion body; abnormal neuron number" "adult locomotory behavior; cellular protein metabolic process; feeding behavior; homeostasis of number of cells within a tissue; insulin-like growth factor receptor signaling pathway; multicellular organism growth; musculoskeletal movement; neuromuscular process controlling balance; post-embryonic development; S phase of mitotic cell cycle; spinal cord motor neuron differentiation" Moq1 Kcnj13 1 89282991 89291302 38 100.0% 0 0.0% 38 100.0% "integral to membrane; inward rectifier potassium channel activity; ion channel activity; ion transmembrane transport; ion transport; membrane; potassium ion transmembrane transport; potassium ion transport; regulation of ion transmembrane transport; transport; voltage-gated ion channel activity" Moq1 3110079O15Rik 1 89366846 89372056 29 85.3% 0 0.0% 34 85.3% "integral to membrane; membrane; biological_process; molecular_function" Moq1 Ngef 1 89373409 89406921 370 92.0% 0 0.0% 402 92.0% abnormal axon outgrowth "cellular process; cell differentiation; cell projection; intracellular; membrane; multicellular organismal development; nervous system development; regulation of catalytic activity; regulation of Rho protein signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptosis; cytoplasm; cytosol; guanyl-nucleotide exchange factor activity; induction of apoptosis by extracellular signals; plasma membrane; regulation of catalytic activity" Moq1 Neu2 1 89491125 89494401 31 100.0% 0 0.0% 31 100.0% "hydrolase activity; hydrolase activity, acting on glycosyl bonds; metabolic process; cytoplasm; cytosol; exo-alpha-sialidase activity; metabolic process; positive regulation of myoblast differentiation; positive regulation of myotube differentiation" Moq1 Inpp5d 1 89516954 89617077 994 96.6% 0 0.0% 1029 96.6% "increased leukocyte cell number; increased neutrophil cell number; increased monocyte cell number; decreased bone marrow cell number; enlarged spleen; spleen hyperplasia; enlarged lymph nodes; enlarged thymus; abnormal lung morphology; decreased body weight; abnormal myelopoiesis; abnormal humoral immune response; premature death; abnormal hematopoiesis; abnormal B cell differentiation; abnormal lymphopoiesis; abnormal leukocyte physiology; abnormal mononuclear cell differentiation; abnormal neutrophil physiology; abnormal eosinophil physiology; abnormal blood coagulation; abnormal hematopoietic stem cell morphology; increased spleen weight; decreased lymphocyte cell number; decreased B cell number; decreased susceptibility to parasitic infection; abnormal NK cell morphology; impaired NK cell cytolysis; abnormal cytotoxic T cell physiology; defective cytotoxic T cell cytolysis; cachexia; abnormal macrophage recruitment; increased bleeding time; decreased susceptibility to graft versus host disease; abnormal platelet activation; increased NK cell number; abnormal granulocyte differentiation; abnormal monocyte differentiation; increased dendritic cell number; absent marginal zone B cells; decreased pro-B cell number; abnormal spleen marginal zone macrophage morphology; abnormal myeloid leukocyte morphology; abnormal lymph node germinal center morphology; abnormal interleukin secretion; increased circulating interleukin-6 level; abnormal interferon level; decreased platelet aggregation" "inositol-polyphosphate 5-phosphatase activity; negative regulation of cell proliferation; phosphatidylinositol trisphosphate phosphatase activity; PTB domain binding; SH3 domain binding; apoptosis; cytoplasm; dephosphorylation; hydrolase activity; inositol or phosphatidylinositol phosphatase activity; membrane; metabolic process; determination of adult lifespan; immunoglobulin mediated immune response; intracellular signal transduction; negative regulation of B cell activation; negative regulation of B cell proliferation; negative regulation of bone resorption; negative regulation of granulocyte differentiation; negative regulation of immune response; negative regulation of interleukin-6 biosynthetic process; negative regulation of monocyte differentiation; negative regulation of neutrophil differentiation; negative regulation of osteoclast differentiation; negative regulation of signal transduction; positive regulation of apoptosis; positive regulation of B cell differentiation; positive regulation of erythrocyte differentiation; positive regulation of lymphocyte differentiation; protein binding; actin filament; cortical cytoskeleton; cytosol; dephosphorylation; inositol-4,5-bisphosphate 5-phosphatase activity; plasma membrane; soluble fraction" Moq1 Atg16l1 1 89652445 89689003 331 87.3% 0 0.0% 379 87.3% "neonatal lethality; abnormal macrophage physiology; abnormal Paneth cell morphology; abnormal autophagy; increased susceptibility to induced colitis; increased interleukin-1 beta secretion; increased interleukin-18 secretion" "autophagic vacuole; autophagy; cytoplasm; membrane; protein transport; transport; protein binding; autophagic vacuole assembly" Moq1 Scarna6 1 89681131 89681395 1 100.0% 0 0.0% 1 100.0% "biological_process; cellular_component; molecular_function" Moq1 5830472F04Rik 1 89692913 89693393 11 84.6% 0 0.0% 13 84.6% "biological_process; cellular_component; molecular_function" Moq1 Sag 1 89700255 89741733 485 75.8% 0 0.0% 640 75.8% "abnormal rod electrophysiology; abnormal cone electrophysiology; abnormal retinal rod cell outer segment morphology; oxidative stress; increased cellular sensitivity to ionizing radiation; increased apoptosis" "opsin binding; phosphoprotein binding; response to stimulus; sensory perception; signal transduction; visual perception; activation of caspase activity; anti-apoptosis; apoptotic mitochondrial changes; cytoplasm; induction of apoptosis by oxidative stress; nucleus; metal ion binding; zinc ion binding; protein binding; NEDD8 ligase activity; protein neddylation; ARF guanyl-nucleotide exchange factor activity; cytoplasm; intracellular; regulation of ARF protein signal transduction; regulation of catalytic activity" Moq1 Dgkd 1 89812155 89841064 187 91.7% 0 0.0% 204 91.7% "eyelids open at birth; respiratory distress; increased tumor incidence; sarcoma; neonatal lethality; seizures; decreased fetal size; abnormal skin physiology; abnormal enzyme/coenzyme activity; decreased birth weight" "activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; ATP binding; intracellular signal transduction; kinase activity; membrane; metal ion binding; nucleotide binding; signal transduction; transferase activity; activating transcription factor binding; cytoplasm; cytoskeleton; cytosol; diacylglycerol kinase activity; G-protein coupled receptor protein signaling pathway; kinase binding; nuclear speck; nucleus; phospholipase binding; phosphorylation; plasma membrane; protein kinase C signaling cascade; regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor; response to ATP; thrombin receptor signaling pathway; cytoplasm; cytoplasmic membrane-bounded vesicle; diacylglycerol kinase activity; diacylglycerol metabolic process; plasma membrane; protein heterodimerization activity; protein homodimerization activity; protein homooligomerization; response to organic substance" Moq1 Usp40 1 89841696 89905126 464 94.1% 0 0.0% 493 94.1% "cysteine-type peptidase activity; hydrolase activity; peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; cellular_component" Moq1 Ugt1a10 1 89951963 90115579 1387 59.0% 1 0.0% 2349 59.1% "endoplasmic reticulum; integral to membrane; membrane; metabolic process; transferase activity; transferase activity, transferring glycosyl groups; transferase activity, transferring hexosyl groups; drug metabolic process; enzyme binding; enzyme inhibitor activity; flavone metabolic process; flavonoid metabolic process; glucuronosyltransferase activity; microsome; negative regulation of fatty acid metabolic process; protein heterodimerization activity; protein homodimerization activity; regulation of catalytic activity; retinoic acid binding; xenobiotic metabolic process; biological_process; cellular_component; molecular_function" Moq1 Ugt1a9 1 89967375 90115572 1231 56.9% 1 0.0% 2163 57.0% "endoplasmic reticulum; integral to membrane; membrane; metabolic process; transferase activity; transferase activity, transferring glycosyl groups; transferase activity, transferring hexosyl groups; drug metabolic process; enzyme binding; enzyme inhibitor activity; flavone metabolic process; flavonoid metabolic process; glucuronosyltransferase activity; microsome; negative regulation of fatty acid metabolic process; protein heterodimerization activity; protein homodimerization activity; regulation of catalytic activity; retinoic acid binding; xenobiotic metabolic process" Moq1 Ugt1a8 1 89984388 90115579 1124 55.5% 1 0.0% 2024 55.6% "aromatic compound catabolic process; coumarin catabolic process; estrogen catabolic process; glucuronosyltransferase activity; membrane fraction; drug metabolic process; enzyme inhibitor activity; fatty acid binding; fatty acid metabolic process; flavone metabolic process; flavonoid metabolic process; glucuronosyltransferase activity; microsome; negative regulation of cellular metabolic process; protein heterodimerization activity; protein homodimerization activity; regulation of catalytic activity; steroid binding; xenobiotic metabolic process" Moq1 Ugt1a7c 1 89991637 90116577 1065 55.2% 1 0.1% 1929 55.3% "aromatic compound catabolic process; coumarin catabolic process; estrogen catabolic process; glucuronosyltransferase activity; membrane fraction" Moq1 Ugt1a6b 1 89999827 90115578 1006 56.0% 1 0.1% 1797 56.0% "transferase activity; transferase activity, transferring glycosyl groups; biological_process; cellular_component" Moq1 Ugt1a6a 1 90031384 90115572 793 69.3% 1 0.1% 1144 69.4% "glucuronate metabolic process; glucuronosyltransferase activity; mitochondrial inner membrane; 4-chlorobiphenyl metabolic process; cellular response to glucocorticoid stimulus; enzyme binding; glucuronate metabolic process; glucuronosyltransferase activity; microsome; protein heterodimerization activity; protein homodimerization activity; xenobiotic metabolic process" Moq1 Ugt1a5 1 90062587 90115572 544 93.5% 0 0.0% 582 93.5% "transferase activity; transferase activity, transferring glycosyl groups; biological_process; cellular_component" Moq1 Ugt1a2 1 90097176 90115572 166 95.4% 0 0.0% 174 95.4% "endoplasmic reticulum; integral to membrane; membrane; metabolic process; microsome; transferase activity; transferase activity, transferring glycosyl groups; transferase activity, transferring hexosyl groups; enzyme binding; flavonoid metabolic process; glucuronosyltransferase activity; protein heterodimerization activity; protein homodimerization activity; retinoic acid binding; xenobiotic metabolic process" Moq1 Dnajb3 1 90101307 90102357 5 100.0% 0 0.0% 5 100.0% "heat shock protein binding; protein folding; unfolded protein binding" Moq1 Ugt1a1 1 90108534 90115572 66 93.0% 0 0.0% 71 93.0% "integral to plasma membrane; endoplasmic reticulum; integral to membrane; membrane; metabolic process; transferase activity; transferase activity, transferring glycosyl groups; transferase activity, transferring hexosyl groups; glucuronosyltransferase activity; biphenyl catabolic process; cytochrome complex; enzyme binding; enzyme inhibitor activity; flavone metabolic process; flavonoid metabolic process; glucuronosyltransferase activity; heme catabolic process; microsome; protein heterodimerization activity; protein homodimerization activity; regulation of catalytic activity; response to organic substance; retinoic acid binding; steroid binding; xenobiotic metabolic process" Moq1 Heatr7b1 1 90123561 90158864 159 75.0% 0 0.0% 212 75.0% "binding; biological_process; cellular_component" Moq1 Hjurp 1 90159046 90174208 71 66.4% 0 0.0% 107 66.4% "cell cycle; DNA binding; CenH3-containing nucleosome assembly at centromere; centromeric core chromatin assembly; chromosome segregation; chromosome, centromeric region; condensed chromosome kinetochore; cytoplasm; histone binding; nucleolus; nucleus" Moq1 Trpm8 1 90174236 90285868 1486 96.3% 0 0.0% 1543 96.3% "abnormal pain threshold; increased thermal nociceptive threshold; abnormal nociception after inflammation; abnormal thermosensation; abnormal neuron physiology" "calcium channel activity; calcium ion transport; cellular calcium ion homeostasis; external side of plasma membrane; ion channel activity; membrane; protein homotetramerization; protein homotrimerization; response to cold; response to temperature stimulus; thermoception; ion transport; receptor activity; response to stimulus; signal transduction; transmembrane transport; transport; calcium channel activity; response to cold; thermoception; protein homodimerization activity; ion channel activity; ion transmembrane transport; response to cold; integral to membrane" Moq1 4930453O03Rik 1 90244064 90249505 68 100.0% 0 0.0% 68 100.0% "biological_process; cellular_component; molecular_function" Moq1 Spp2 1 90303536 90323013 341 99.7% 0 0.0% 342 99.7% "intracellular; nucleic acid binding; nucleus; biological_process; bone remodeling; extracellular region; protein complex; protein complex assembly; molecular_function; catalytic activity; hydrolase activity; integral to membrane; membrane; metabolic process; dephosphorylation; endoplasmic reticulum; sphingosine metabolic process; sphingosine-1-phosphate phosphatase activity" Moq1 Glrp1 1 90396446 90406641 75 56.0% 0 0.0% 134 56.0% "nucleus; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; Notch signaling pathway; nucleus; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity" Moq1 Arl4c 1 90569700 90598796 381 74.4% 0 0.0% 512 74.4% "cell projection; GTP binding; intracellular; nucleotide binding; small GTPase mediated signal transduction; transport; alpha-tubulin binding; cytoplasm; endocytic recycling; plasma membrane" Moq1 2410088K16Rik 1 90651471 90652310 17 89.5% 0 0.0% 19 89.5% "biological_process; cellular_component; molecular_function" Moq1 Sh3bp4 1 90966990 91051643 776 75.6% 0 0.0% 1026 75.6% "coated pit; cytoplasmic vesicle; endocytosis; membrane; nucleus; molecular_function" Moq1 Gm7750 1 91292790 91297474 102 83.6% 0 0.0% 122 83.6% "biological_process; cellular_component; molecular_function" Moq1 Agap1 1 91351386 91791857 4544 83.6% 0 0.0% 5436 83.6% "ARF GTPase activator activity; cytoplasm; GTP binding; GTPase activator activity; intracellular; metal ion binding; nucleotide binding; protein transport; regulation of ARF GTPase activity; small GTPase mediated signal transduction; transport; zinc ion binding; cytosol; GTPase activity" Moq1 Gbx2 1 91824559 91827751 23 95.8% 0 0.0% 24 95.8% "small ears; abnormal inner ear morphology; absent scala media; abnormal membranous labyrinth; absent endolymphatic duct; abnormal organ of Corti; short mandible; cleft palate; abnormal heart morphology; overriding aorta; double outlet heart right ventricle; abnormal thymus development; abnormal inferior colliculus; increased inferior colliculus size; abnormal choroid plexus morphology; abnormal thalamus morphology; abnormal hindbrain morphology; abnormal pons morphology; abnormal cerebellum morphology; absent cerebellum; abnormal cerebellum development; abnormal cerebellar foliation; cerebellum vermis hypoplasia; abnormal midbrain morphology; abnormal brain development; exencephaly; abnormal rhombomere morphology; abnormal telencephalon development; abnormal motor neuron morphology; absent trigeminal nerve; abnormal trigeminal ganglion morphology; decreased body weight; abnormal eye development; cyanosis; decreased embryo size; abnormal postnatal growth; neonatal lethality; postnatal lethality; abnormal cardiovascular system morphology; abnormal neural tube morphology/development; no abnormal phenotype detected; abnormal innervation; abnormal branchial arch artery morphology; abnormal neural crest cell migration; absent cochlear ganglion; decreased cochlear coiling; absent lateral semicircular canal; absent posterior semicircular canal; absent superior semicircular canal; abnormal forebrain development; abnormal cochlear sensory epithelium morphology; abnormal vascular endothelial cell differentiation; abnormal locus ceruleus; fusion of middle ear ossicles; abnormal midbrain development; absent branchial arches; abnormal craniofacial development; abnormal midbrain-hindbrain boundary development; abnormal aortic arch morphology; interrupted aortic arch; right aortic arch; retroesophageal right subclavian artery; abnormal crista ampullaris morphology; abnormal embryonic neuroepithelium morphology; small otic vesicle; absent saccule; abnormal saccular macula morphology; absent supraoccipital bone; fusion of glossopharyngeal and vagus nerve; absent common crus; dilated heart; abnormal middle ear ossicle morphology; abnormal neural plate morphology; abnormal hindbrain development; abnormal isthmic organizer morphology; embryonic lethality during organogenesis; inner ear cysts; otic capsule hypoplasia; absent olfactory placodes; abnormal fourth branchial arch artery morphology; abnormal styloid process morphology; decreased neural crest cell number; abnormal neural crest cell morphology; perimembraneous ventricular septal defect" "DNA binding; nucleus; regulation of transcription; regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription; transcription regulator activity; patterning of blood vessels; autonomic nervous system development; axon guidance; cell proliferation; cerebellar granule cell precursor proliferation; cerebellum development; hindbrain development; inner ear morphogenesis; midbrain-hindbrain boundary development; midbrain-hindbrain boundary morphogenesis; neural crest cell migration; patterning of blood vessels; rhombomere 2 development; tube morphogenesis" Moq1 Asb18 1 91849253 91911152 946 99.4% 0 0.0% 952 99.4% "intracellular signal transduction; cellular_component; molecular_function" Moq1 Iqca 1 91938710 92042113 949 80.5% 0 0.0% 1179 80.5% "ATP binding; metabolic process; nucleoside-triphosphatase activity; nucleotide binding; cellular_component" Moq1 Cxcr7 1 92100555 92113326 121 89.0% 0 0.0% 136 89.0% "abnormal heart morphology; overriding aorta; enlarged heart; heart hyperplasia; abnormal myocardial fiber morphology; abnormal interventricular septum morphology; abnormal atrioventricular cushion morphology; abnormal cardiovascular system physiology; cyanosis; cardiac hypertrophy; atrial thrombosis; lung inflammation; hemorrhage; respiratory distress; neonatal lethality; perinatal lethality; postnatal lethality; premature death; heart left ventricle hypertrophy; abnormal semilunar valve morphology; abnormal aortic valve morphology; abnormal pulmonary valve morphology; dilated heart right ventricle; dilated heart atrium; cardiac fibrosis; enlarged myocardial fiber; myocardial fiber degeneration; pulmonary fibrosis; aortic valve calcification; aortic valve stenosis; abnormal outflow tract development; pulmonary valve stenosis; decreased marginal zone B cell number; decreased survivor rate; ventricular septal defect; atrial septal defect; perimembraneous ventricular septal defect; abnormal heart and great artery attachment; thick aortic valve; thick pulmonary valve" "G-protein coupled receptor activity; G-protein coupled receptor protein signaling pathway; integral to membrane; membrane; receptor activity; signal transducer activity; signal transduction; plasma membrane" Moq1 Cops8 1 92500074 92509699 105 70.9% 0 0.0% 148 70.9% "decreased embryo size; abnormal T cell activation; prenatal lethality; abnormal cell cycle; embryonic growth retardation; abnormal inner cell mass proliferation; decreased T cell number; decreased T cell proliferation; abnormal CD4-positive T cell physiology; decreased interleukin-2 secretion" "nucleus; signalosome; cytoplasm; protein binding" Moq1 Gm9991 1 92571736 92576368 59 77.6% 0 0.0% 76 77.6% "biological_process; cellular_component; molecular_function" Moq1 Col6a3 1 92663435 92740529 1120 67.1% 0 0.0% 1668 67.1% "extracellular matrix; extracellular space; sarcolemma" Moq1 Mlph 1 92811662 92847719 786 98.7% 1 0.1% 796 98.9% "diluted coat color; prenatal lethality; decreased bleeding time; abnormal hair follicle melanin granule distribution; abnormal choroid melanin granule morphology" "actin binding; actin cytoskeleton; melanosome; myosin binding; Rab GTPase binding; intracellular protein transport; metal ion binding; zinc ion binding; melanocyte differentiation; melanosome localization; pigmentation; protein targeting; microtubule plus-end binding; myosin V binding; protein binding; melanosome" Moq1 Prlh 1 92849685 92850589 16 100.0% 0 0.0% 16 100.0% "increased brown adipose tissue amount; increased white adipose tissue amount; increased body weight; obese; increased circulating triglyceride level; increased circulating insulin level; hepatic steatosis; increased eating behavior; impaired glucose tolerance; insulin resistance; increased susceptibility to diet-induced obesity; increased circulating leptin level; increased fat cell size; abnormal autonomic nervous system physiology; increased liver triglyceride level" "autonomic nervous system development; eating behavior; energy reserve metabolic process; fat cell differentiation; lipid metabolic process; regulation of multicellular organism growth; response to dietary excess; response to glucose stimulus; response to insulin stimulus; response to peptide hormone stimulus; tissue homeostasis; cytoplasm; feeding behavior; G-protein coupled receptor protein signaling pathway; neuropeptide hormone activity; prolactin-releasing peptide receptor binding; reduction of food intake in response to dietary excess" Moq1 Rab17 1 92854710 92866238 341 97.7% 3 0.9% 349 98.6% "GTP binding; membrane; nucleotide binding; plasma membrane; protein transport; small GTPase mediated signal transduction; transport; intracellular" Moq1 Lrrfip1 1 92950084 93025495 991 63.7% 0 0.0% 1556 63.7% "cytoplasm; DNA binding; nucleus; regulation of transcription; transcription; protein binding" Moq1 Rbm44 1 93041680 93067372 191 66.3% 1 0.3% 288 66.7% "nucleic acid binding; nucleotide binding; RNA binding; biological_process; cellular_component" Moq1 Ramp1 1 93076623 93120973 498 72.8% 26 3.8% 684 76.6% "abnormal cytokine secretion; decreased vasodilation; increased systemic arterial systolic blood pressure; increased circulating tumor necrosis factor level; increased circulating interferon-gamma level; increased circulating interleukin-6 level; abnormal chemokine secretion" "coreceptor activity; integral to membrane; intracellular protein transport; membrane; protein transporter activity; receptor activity; regulation of G-protein coupled receptor protein signaling pathway; transport; G-protein coupled receptor protein signaling pathway; coreceptor activity; extracellular space; plasma membrane; signal transduction" Moq1 Ube2f 1 93180239 93181593 10 90.9% 0 0.0% 11 90.9% "NEDD8 ligase activity; protein neddylation; cellular_component" Moq1 Scly 1 93194915 93217652 403 97.8% 1 0.2% 412 98.1% "catalytic activity; cytoplasm; lyase activity; metabolic process; pyridoxal phosphate binding; selenocysteine lyase activity; transferase activity" Moq1 Espnl 1 93218652 93244880 465 90.1% 2 0.4% 516 90.5% "biological_process; cellular_component; molecular_function" Moq1 Klhl30 1 93247593 93258993 175 98.9% 1 0.6% 177 99.4% "biological_process; cellular_component; molecular_function" Moq1 Fam132b 1 93263007 93270793 99 90.8% 0 0.0% 109 90.8% "extracellular region; biological_process; molecular_function" Moq1 Ilkap 1 93272408 93295360 196 83.8% 2 0.9% 234 84.6% "catalytic activity; cytoplasm; hydrolase activity; metal ion binding; phosphoprotein phosphatase activity; protein serine/threonine phosphatase complex; negative regulation of cell cycle; protein dephosphorylation; protein serine/threonine phosphatase activity; regulation of S phase of mitotic cell cycle" Moq1 1700020N18Rik 1 93301460 93304748 14 56.0% 0 0.0% 25 56.0% "biological_process; cellular_component; molecular_function" Moq1 Hes6 1 93308060 93310615 24 88.9% 0 0.0% 27 88.9% "cell differentiation; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription cofactor activity; transcription factor complex; DNA binding; multicellular organismal development; nucleus; regulation of transcription; regulation of transcription, DNA-dependent; transcription; transcription regulator activity; nervous system development; regulation of transcription from RNA polymerase II promoter" Moq1 Per2 1 93312559 93355873 604 86.2% 0 0.0% 701 86.2% "salivary gland epithelial hyperplasia; abnormal body weight; increased body weight; pup cannibalization; abnormal locomotor activity; abnormal food preference; abnormal sleep pattern; increased mortality induced by gamma-irradiation; abnormal body temperature regulation; reduced female fertility; decreased litter size; increased lymphoma incidence; premature death; abnormal skeleton development; no abnormal phenotype detected; abnormal bone marrow cell morphology/development; addiction; arrhythmic circadian persistence; prolonged circadian period; shortened circadian period; advanced circadian phase; abnormal preputial gland morphology; decreased cellular sensitivity to gamma-irradiation; increased incidence of ionizing radiation-induced tumors; increased osteoblast cell number; abnormal brain wave pattern; abnormal osteoblast physiology; abnormal food intake; increased bone mass; increased circulating leptin level; abnormal maternal behavior; abnormal basal metabolism; early reproductive senescence; prolonged estrous cycle; absent estrous cycle; abnormal urine homeostasis; abnormal pregnancy; enhanced conditioned place preference behavior; increased salivary gland tumor incidence" "circadian rhythm; cytoplasm; negative regulation of gene-specific transcription from RNA polymerase II promoter; regulation of transcription; regulation of transcription, DNA-dependent; rhythmic process; signal transducer activity; signal transduction; transcription; nucleus; protein binding; nucleus" Moq1 Traf3ip1 1 93391254 93424841 347 78.2% 0 0.0% 444 78.2% "cytoplasm; cytoskeleton; cytosol; microtubule binding; microtubule cytoskeleton; negative regulation of transcription from RNA polymerase II promoter; negative regulation of tyrosine phosphorylation of Stat6 protein; receptor binding; regulation of DNA binding; tubulin binding" Moq1 Asb1 1 93437142 93456167 119 79.3% 0 0.0% 150 79.3% "small spleen; spleen hypoplasia; abnormal testis morphology; abnormal spermatogenesis; thickened epidermis" "intracellular signal transduction; multicellular organismal development; male genitalia development; cellular_component; molecular_function" Moq1 Twist2 1 93698038 93744605 639 82.2% 0 0.0% 777 82.2% "delayed bone ossification; decreased bone mineral density; abnormal fontanelle morphology; abnormal sphenoid bone morphology; abnormal cancellous bone morphology; abnormal long bone metaphysis morphology; abnormal vertebrae morphology; abnormal long bone hypertrophic chondrocyte zone; abnormal chondrocyte morphology; hypoglycemia; decreased cell proliferation; abnormal hair follicle morphology; decreased hair follicle number; sparse hair; domed cranium; abnormal small intestine morphology; short limbs; abnormal hepatocyte morphology; abnormal spleen morphology; abnormal thymus morphology; abnormal skeletal muscle morphology; abnormal lung development; lung hemorrhage; thin skin; epidermal atrophy; hyperkeratosis; thin dermal layer; abnormal digestive system physiology; postnatal growth retardation; respiratory distress; neonatal lethality; postnatal lethality; abnormal skeleton development; abnormal axial skeleton morphology; no abnormal phenotype detected; abnormal spleen white pulp morphology; abnormal thymus cortex morphology; abnormal thymus medulla morphology; disproportionate dwarf; short tibia; short fibula; abnormal joint morphology; abnormal thoracic vertebrae morphology; abnormal cervical vertebrae morphology; short femur; fused synovial joints; decreased width of hypertrophic chondrocyte zone; small lung; thymus atrophy; abnormal synchondrosis; clavicle hypoplasia; small interparietal bone; short presphenoid bone; absent vertebral spinous process; abnormal small intestine crypts of Lieberkuhn morphology; decreased osteoblast cell number; abnormal osteoblast physiology; cachexia; abnormal vertebrae development; dystonia; decreased glycogen level; impaired bronchiole branching; abnormal interscapular fat pad morphology; abnormal bone ossification; abnormal endochondral bone ossification; failure of endochondral bone ossification; abnormal osteoblast differentiation; abnormal osteoclast differentiation; postnatal slow weight gain; polycystic kidney; abnormal interleukin level; abnormal tumor necrosis factor level; absent subcutaneous adipose tissue; abnormal brown fat cell morphology; abnormal appendicular skeleton morphology; decreased total body fat amount; abnormal basicranium morphology" "chromatin binding; negative regulation of molecular function; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription repressor activity; cell differentiation; DNA binding; multicellular organismal development; regulation of transcription; transcription; transcription regulator activity; embryonic cranial skeleton morphogenesis; negative regulation of tumor necrosis factor production; negative regulation of osteoblast differentiation; negative regulation of tumor necrosis factor production; osteoblast differentiation; protein binding; protein domain specific binding; transcription factor complex; anti-apoptosis; cytoplasm; negative regulation of osteoblast differentiation; nucleus" Moq1 Hdac4 1 93829311 94044970 1356 68.7% 0 0.0% 1973 68.7% "abnormal osteogenesis; premature suture closure; abnormal vertebrae morphology; abnormal long bone hypertrophic chondrocyte zone; domed cranium; exencephaly; convulsive seizures; decreased body weight; decreased body size; hyperactivity; increased thermal nociceptive threshold; increased blinking frequency; postnatal lethality; tonic seizures; premature endochondral bone ossification; abnormal involuntary movement; abnormal motor nerve collateral sprouting; abnormal costal cartilage morphology; abnormal spike wave discharge; environmentally induced seizures; abnormal skeletal muscle fiber type ratio" "actomyosin; cytosol; DNA binding; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neuromuscular junction; protein deacetylase activity; transcription repressor activity; chromatin modification; histone deacetylase activity (H3-K14 specific); histone deacetylase activity (H3-K16 specific); histone deacetylase activity (H3-K9 specific); hydrolase activity; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); regulation of transcription; transcription; negative regulation of transcription from RNA polymerase II promoter; regulation of skeletal muscle fiber development; regulation of striated muscle cell differentiation; transcription corepressor activity; cytoplasm; negative regulation of cell proliferation; negative regulation of glycolysis; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent; nucleus; osteoblast development; positive regulation of gene-specific transcription from RNA polymerase II promoter; regulation of cardiac muscle contraction by calcium ion signaling; response to denervation involved in regulation of muscle adaptation; skeletal system development; transcription activator activity; transcription repressor activity; protein binding; A band; activating transcription factor binding; chromatin remodeling; cytoplasm; histone deacetylase activity; histone deacetylase binding; histone deacetylase complex; histone deacetylation; histone H3 deacetylation; histone H4 deacetylation; negative regulation of gene-specific transcription from RNA polymerase II promoter; negative regulation of myotube differentiation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; peptidyl-lysine deacetylation; positive regulation of cell proliferation; positive regulation of gene-specific transcription from RNA polymerase II promoter; positive regulation of protein sumoylation; positive regulation of transcription factor activity; potassium ion binding; protein deacetylase activity; regulation of protein binding; repressing transcription factor binding; response to drug; response to interleukin-1; sarcomere; specific transcriptional repressor activity; transcription factor binding; transcription repressor activity; transcriptional repressor complex; Z disc; zinc ion binding" Moq1 Ndufa10 1 94335587 94370437 372 76.7% 0 0.0% 485 76.7% "mitochondrion; ATP binding; electron transport chain; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; phosphotransferase activity, alcohol group as acceptor; respiratory chain; transport; mitochondrial respiratory chain complex I" Moq1 Olfr1416 1 94376258 94377196 8 50.0% 0 0.0% 16 50.0% "G-protein coupled receptor activity; receptor activity; signal transducer activity; signal transduction; G-protein coupled receptor protein signaling pathway; integral to membrane; olfactory receptor activity; sensory perception of smell" Moq1 Olfr1415 1 94387395 94388330 5 41.7% 0 0.0% 12 41.7% "G-protein coupled receptor activity; receptor activity; signal transducer activity; signal transduction; G-protein coupled receptor protein signaling pathway; integral to membrane; olfactory receptor activity; sensory perception of smell" Moq1 Olfr1414 1 94407665 94408603 10 58.8% 0 0.0% 17 58.8% "G-protein coupled receptor activity; receptor activity; signal transducer activity; signal transduction; G-protein coupled receptor protein signaling pathway; integral to membrane; olfactory receptor activity; sensory perception of smell" Moq1 Olfr1413 1 94469750 94470721 14 93.3% 0 0.0% 15 93.3% "G-protein coupled receptor activity; receptor activity; signal transducer activity; signal transduction; G-protein coupled receptor protein signaling pathway; integral to membrane; olfactory receptor activity; sensory perception of smell" Moq1 Olfr1412 1 94484909 94485874 13 81.3% 0 0.0% 16 81.3% "G-protein coupled receptor activity; receptor activity; signal transducer activity; signal transduction; G-protein coupled receptor protein signaling pathway; integral to membrane; olfactory receptor activity; sensory perception of smell" Moq1 Olfr1411 1 94493098 94494069 13 68.4% 0 0.0% 19 68.4% "G-protein coupled receptor activity; receptor activity; signal transducer activity; signal transduction; G-protein coupled receptor protein signaling pathway; integral to membrane; olfactory receptor activity; sensory perception of smell" Moq1 Olfr1410 1 94504416 94505384 12 85.7% 0 0.0% 14 85.7% "G-protein coupled receptor activity; receptor activity; signal transducer activity; signal transduction; G-protein coupled receptor protein signaling pathway; integral to membrane; olfactory receptor activity; sensory perception of smell" Moq1 Olfr12 1 94516485 94517486 10 55.6% 0 0.0% 18 55.6% "G-protein coupled receptor activity; membrane; plasma membrane; receptor activity; response to stimulus; signal transducer activity; signal transduction; G-protein coupled receptor protein signaling pathway; integral to membrane; olfactory receptor activity; sensory perception of smell" Moq1 Myeov2 1 94533722 94538562 40 81.6% 0 0.0% 49 81.6% "biological_process; cellular_component; molecular_function" Moq1 Otos 1 94540795 94545418 83 93.3% 0 0.0% 89 93.3% "abnormal cochlea morphology; deafness; abnormal type II spiral ligament fibrocytes; abnormal type IV spiral ligament fibrocytes; decreased cochlear microphonics; decreased cochlear nerve compound action potential" "extracellular region; sensory perception of sound; sensory perception of sound" Moq1 Gpc1 1 94728263 94756773 269 81.0% 0 0.0% 332 81.0% "decreased metastatic potential; abnormal response/metabolism to endogenous compounds" "anchored to membrane; extracellular region; heparan sulfate proteoglycan binding; membrane; proteinaceous extracellular matrix; plasma membrane" Moq1 Mir149 1 94746955 94747020 0 #DIV/0! 0 #DIV/0! 0 - Moq1 Ankmy1 1 94766706 94799483 357 93.7% 0 0.0% 381 93.7% "metal ion binding; zinc ion binding; biological_process; cellular_component" Moq1 Dusp28 1 94803566 94805005 21 95.5% 0 0.0% 22 95.5% "dephosphorylation; hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein dephosphorylation; protein tyrosine phosphatase activity; peptidyl-tyrosine dephosphorylation; protein tyrosine/serine/threonine phosphatase activity; cellular_component" Moq1 Gm2816 1 94805653 94807523 26 96.3% 0 0.0% 27 96.3% "biological_process; cellular_component; molecular_function" Moq1 Rnpepl1 1 94807982 94817156 87 97.8% 0 0.0% 89 97.8% "aminopeptidase activity; metabolic process; cellular_component" Moq1 9430060I03Rik 1 94830743 94831024 1 25.0% 0 0.0% 4 25.0% "biological_process; cellular_component; molecular_function" Moq1 Capn10 1 94830953 94844518 108 69.7% 0 0.0% 155 69.7% "increased body weight; decreased circulating triglyceride level; abnormal pancreas physiology; decreased circulating free fatty acid level; increased heart weight; increased liver weight; increased kidney weight; increased spleen weight; decreased circulating cholesterol level; decreased circulating glucose level; increased circulating leptin level; increased total fat pad weight; increased gonadal fat pad weight; increased inguinal fat pad weight; increased mesenteric fat pad weight; increased renal fat pad weight" "cysteine-type endopeptidase activity; cysteine-type peptidase activity; hydrolase activity; intracellular; peptidase activity; actin cytoskeleton reorganization; cellular response to insulin stimulus; positive regulation of apoptosis; positive regulation of glucose import; positive regulation of intracellular transport; actin cytoskeleton reorganization; aging; calcium-dependent cysteine-type endopeptidase activity; cell; cell cortex; cellular response to insulin stimulus; cytoplasm; cytoskeletal protein binding; cytoskeleton; cytosol; microsome; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial matrix; mitochondrial outer membrane; nucleus; plasma membrane; positive regulation of apoptosis; positive regulation of glucose import; positive regulation of insulin secretion; proteolysis; response to nutrient levels; SNARE binding" Moq1 Gpr35 1 94875698 94882109 69 93.2% 0 0.0% 74 93.2% "integral to plasma membrane; integral to membrane; membrane; plasma membrane; receptor activity; signal transducer activity; signal transduction; G-protein coupled receptor activity; G-protein coupled receptor protein signaling pathway; integral to plasma membrane" Moq1 Aqp12 1 94902911 94908843 59 83.1% 0 0.0% 71 83.1% "increased cholesterol level; increased susceptibility to induced pancreatitis; abnormal pancreatic acinar cell zymogen granule" "cytoplasm; integral to membrane; membrane; transport; transporter activity" Moq1 Kif1a 1 94914855 94998399 5700 98.4% 0 0.0% 5794 98.4% "ataxia; hypoactivity; unresponsive to tactile stimuli; abnormal motor coordination/ balance; impaired balance; neonatal lethality; postnatal lethality; neuron degeneration; abnormal nervous system physiology; abnormal synaptic vesicle number; abnormal synaptic vesicle clustering; axon degeneration; hyporesponsive to tactile stimuli; decreased birth weight; decreased birth body size" "ATP binding; cytoskeleton; metabolic process; microtubule; microtubule motor activity; microtubule-based movement; motor activity; nucleotide binding; cytoplasm; nucleus" EOL