Supplementary Table 1.  Donor population    
Telomere  p16 gene 
Donor 
ID. Age Gender 
Final 
PD 
Culture 
Period 
(days) 
Early 
mTRFL 
(kb)  
Late 
mTRFL 
(kb) 
Shortening 
ratio (bp)  Group
a Methylationb
                     
hMSC08 67 F 25 164 6.7 6.5 30  GI ND 
hMSC09 66 M 29 175 10.8 8.1 150  GI ND 
hMSC15 42 M 27 117 9.4 7.1 120  GI ND 
hMSC16 63 F 18 132 8.5 7.1 200  GI - 
hMSC18 49 F 26 116 7.8 6.4 90  GI ND 
hMSC19 20 M 31 147 9.9 7.2 120  GI ND 
hMSC21 57 M 22 123 9.9 8.4 120  GI ND 
hMSC22 65 M 27 113 9.2 7.1 110  GI ND 
hMSC23 29 F 29 151 9.9 7.2 160  GI ND 
hMSC25 66 M 27 149 8.5 7.4 50  GI ND 
hMSC28 28 M 28 117 10.0 7.4 170  GI - 
hMSC29 51 F 25 132 10.1 8.0 140  GI - 
hMSC34 77 F 27 159 9.9 8.8 60  GI - 
hMSC35 69 F 27 153 9.8 7.2 140  GI - 
hMSC36 44 M 28 180 9.1 7.8 70  GI - 
hMSC37 42 F 37 240 10.9 7.6 120  GI - 
hMSC38 84 M 13 125 8.3 8.0 50  GI - 
hMSC39 19 M 35 181 9.8 7.6 100  GI - 
hMSC40 18 M 39 199 8.9 7.3 60  GI - 
hMSC41 70 M 25 145 9.3 8.5 60  GI - 
hMSC42 29 F 30 167 9.9 7.5 110  GI - 
hMSC43 58 F 30 112 9.4 7.8 80  GI ND 
hMSC44 74 F 18 100 7.1 6.7 200  GI ND 
hMSC45 53 M 29 111 9.4 7.1 100  GI ND 
hMSC46 71 F 24 90 8.8 6.9 100  GI ND 
         
hMSC14 17 F 33 147 9.5 7.6 110  IR + 
hMSC17 24 F 54 334 11.5 6.9 130  IR + 
         
hMSC10 74 F 28 138 10.3 8.5 100  NI + 
hMSC24 10 F 27 170 9.0 7.1 100  NI + 
         
Average 49.1  28.1 151.2 9.4 7.5 109    
Stdev 21.8   7.2 47.7 1.0 0.6 43